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10.1371/journal.pone.0145148 http://scihub22266oqcxt.onion/10.1371/journal.pone.0145148 C4683060!4683060!26679937     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (12): ä Nephropedia Template TP {{tp|p=26679937|t=2015. Characterization of Lung Fibroblasts More than Two Decades after Mustard Gas Exposure |pdf=|usr=}}{{26679937}} gab.com Text Characterization of Lung Fibroblasts More than Two Decades after Mustard Gas Exposure JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26679937 #FOAvip Purpose: In patients with short-term exposure to the sulfur mustard gas, the delayed cellular effects on lungs have not been well understood yet. The lung pathology shows a dominant feature consistent with obliterative bronchiolitis, in which fibroblasts play a central role. This study aims to characterize alterations to lung fibroblasts, at the cellular level, in patients with delayed respiratory complications after short-term exposure to the sulfur mustard gas. Methods: Fibroblasts were isolated from the transbronchial biopsies of patients with documented history of exposure to single high-dose sulfur mustard during 1985?7 and compared with the fibroblasts of control subjects. Results: Compared with controls, patients? fibroblasts were thinner and shorter, and showed a higher population doubling level, migration capacity and number of filopodia. Sulfur mustard decreased the in vitro viability of fibroblasts and increased their sensitivity to induction of apoptosis, but did not change the rate of spontaneous apoptosis. In addition, higher expression of alpha smooth muscle actin showed that the lung's microenvironment in these patients is permissive for myofibroblastic differentiation. Conclusions: These findings suggest that in patients under the study, the delayed pulmonary complications of sulfur mustard should be considered as a unique pathology, which might need a specific management by manipulation of cellular components. Twit Text FOAVip Characterization of Lung Fibroblasts More than Two Decades after Mustard Gas Exposure ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26679937 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26679937 #FOAvip English Wikipedia <ref>{{Cite pmid|26679937}}</ref> Characterization of Lung Fibroblasts More than Two Decades after Mustard Gas Exposure #MMPMID26679937 Pirzad Jahromi G; Ghanei M; Hosseini SK; Shamsaei A; Gholipourmalekabadi M; Koochaki A; Karkuki Osguei N; Samadikuchaksaraei A PLoS One 2015[]; 10 (12): ä PMID26679937show ga Purpose: In patients with short-term exposure to the sulfur mustard gas, the delayed cellular effects on lungs have not been well understood yet. The lung pathology shows a dominant feature consistent with obliterative bronchiolitis, in which fibroblasts play a central role. This study aims to characterize alterations to lung fibroblasts, at the cellular level, in patients with delayed respiratory complications after short-term exposure to the sulfur mustard gas. Methods: Fibroblasts were isolated from the transbronchial biopsies of patients with documented history of exposure to single high-dose sulfur mustard during 1985?7 and compared with the fibroblasts of control subjects. Results: Compared with controls, patients? fibroblasts were thinner and shorter, and showed a higher population doubling level, migration capacity and number of filopodia. Sulfur mustard decreased the in vitro viability of fibroblasts and increased their sensitivity to induction of apoptosis, but did not change the rate of spontaneous apoptosis. In addition, higher expression of alpha smooth muscle actin showed that the lung's microenvironment in these patients is permissive for myofibroblastic differentiation. Conclusions: These findings suggest that in patients under the study, the delayed pulmonary complications of sulfur mustard should be considered as a unique pathology, which might need a specific management by manipulation of cellular components. äCharacterization of Lung Fibroblasts More than Two Decades after Musta(epmc).pdf DeepDyve Pubget Overpricing