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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Mol+Biol+Rep
2015 ; 1
(3
): 115-123
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Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis,
Homeostasis, and Repair
#MMPMID26688786
Makarenkova HP
; Dartt DA
Curr Mol Biol Rep
2015[Sep]; 1
(3
): 115-123
PMID26688786
show ga
Lacrimal gland (LG) is an exocrine tubuloacinar gland that secretes the aqueous
layer of the tear film. LG epithelium is composed of ductal, acinar, and
myoepithelial cells (MECs) bordering the basal lamina and separating the
epithelial layer from the extracellular matrix. Mature MECs have contractile
ability and morphologically resemble smooth muscle cells; however, they exhibit
features typical for epithelial cells, such as the presence of specific
cytokeratin filaments. Increasing evidence supports the assertion that
myoepithelial cells (MECs) play key roles in the lacrimal gland development,
homeostasis, and stabilizing the normal structure and polarity of LG secretory
acini. MECs take part in the formation of extracellular matrix gland and
participate in signal exchange between epithelium and stroma. MECs have a high
level of plasticity and are able to differentiate into several cell lineages.
Here, we provide a review on some of the MEC characteristics and their role in LG
morphogenesis, maintenance, and repair.