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10.1371/journal.pone.0144372 http://scihub22266oqcxt.onion/10.1371/journal.pone.0144372 C4683005!4683005!26680360     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (12): ä Nephropedia Template TP {{tp|p=26680360|t=2015. A Novel Anti-Inflammatory Effect for High Density Lipoprotein |pdf=|usr=}}{{26680360}} gab.com Text A Novel Anti-Inflammatory Effect for High Density Lipoprotein JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26680360 #FOAvip High density lipoprotein has anti-inflammatory effects in addition to mediating reverse cholesterol transport. While many of the chronic anti-inflammatory effects of high density lipoprotein (HDL) are attributed to changes in cell adhesion molecules, little is known about acute signal transduction events elicited by HDL in endothelial cells. We now show that high density lipoprotein decreases endothelial cell exocytosis, the first step in leukocyte trafficking. ApoA-I, a major apolipoprotein of HDL, mediates inhibition of endothelial cell exocytosis by interacting with endothelial scavenger receptor-BI which triggers an intracellular protective signaling cascade involving protein kinase C (PKC). Other apolipoproteins within the HDL particle have only modest effects upon endothelial exocytosis. Using a human primary culture of endothelial cells and murine apo-AI knockout mice, we show that apo-AI prevents endothelial cell exocytosis which limits leukocyte recruitment. These data suggest that high density lipoprotein may inhibit diseases associated with vascular inflammation in part by blocking endothelial exocytosis. Twit Text FOAVip A Novel Anti-Inflammatory Effect for High Density Lipoprotein ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26680360 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26680360 #FOAvip English Wikipedia <ref>{{Cite pmid|26680360}}</ref> A Novel Anti-Inflammatory Effect for High Density Lipoprotein #MMPMID26680360 Cameron SJ; Morrell CN; Bao C; Swaim AF; Rodriguez A; Lowenstein CJ PLoS One 2015[]; 10 (12): ä PMID26680360show ga High density lipoprotein has anti-inflammatory effects in addition to mediating reverse cholesterol transport. While many of the chronic anti-inflammatory effects of high density lipoprotein (HDL) are attributed to changes in cell adhesion molecules, little is known about acute signal transduction events elicited by HDL in endothelial cells. We now show that high density lipoprotein decreases endothelial cell exocytosis, the first step in leukocyte trafficking. ApoA-I, a major apolipoprotein of HDL, mediates inhibition of endothelial cell exocytosis by interacting with endothelial scavenger receptor-BI which triggers an intracellular protective signaling cascade involving protein kinase C (PKC). Other apolipoproteins within the HDL particle have only modest effects upon endothelial exocytosis. Using a human primary culture of endothelial cells and murine apo-AI knockout mice, we show that apo-AI prevents endothelial cell exocytosis which limits leukocyte recruitment. These data suggest that high density lipoprotein may inhibit diseases associated with vascular inflammation in part by blocking endothelial exocytosis. äA Novel Anti-Inflammatory Effect for High Density Lipoprotein (epmc).pdf DeepDyve Pubget Overpricing