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10.1016/j.celrep.2015.05.012 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.05.012 C4682876!4682876!26051937     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 11 (10): 1591-603 Nephropedia Template TP {{tp|p=26051937|t=2015. Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway |pdf=|usr=}}{{26051937}} gab.com Text Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26051937 #FOAvip Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER stress, allowing preservation of the lungs and survival. We propose that ER stress resulting from recognition of non-adapted viruses is utilized to discriminate ?non-self? at the level of protein processing and to activate immune responses, with unintended consequences on pathogenesis. Understanding this mechanism should improve strategies for treating acute lung injury from zoonotic viral infections. Twit Text FOAVip Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26051937 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26051937 #FOAvip English Wikipedia <ref>{{Cite pmid|26051937}}</ref> Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway #MMPMID26051937 Hrincius E; Liedmann S; Finkelstein D; Vogel P; Gansebom S; Samarasinghe A; You D; Cormier S; McCullers J Cell Rep 2015[Jun]; 11 (10): 1591-603 PMID26051937show ga Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER stress, allowing preservation of the lungs and survival. We propose that ER stress resulting from recognition of non-adapted viruses is utilized to discriminate ?non-self? at the level of protein processing and to activate immune responses, with unintended consequences on pathogenesis. Understanding this mechanism should improve strategies for treating acute lung injury from zoonotic viral infections. äAcute Lung Injury Results from Innate Sensing of Viruses by an ER Stre(epmc).pdf DeepDyve Pubget Overpricing