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10.15252/embj.201591407 http://scihub22266oqcxt.onion/10.15252/embj.201591407 C4682649!4682649 !26459514     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26459514 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2015 ; 34 (22 ): 2775-88 Nephropedia Template TP {{tp|p=26459514 |t=2015. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14 |pdf=|usr=}}{{26459514 }} gab.com Text Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14 JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26459514 #FOAvip The intracellular chaperone heat-shock protein 70 (Hsp70) can be secreted from cells, but its extracellular role is unclear, as the protein has been reported to both activate and suppress the innate immune response. Potential immunomodulatory receptors on myelomonocytic lineage cells that bind extracellular Hsp70 are not well defined. Siglecs are Ig-superfamily lectins on mammalian leukocytes that recognize sialic acid-bearing glycans and thereby modulate immune responses. Siglec-5 and Siglec-14, expressed on monocytes and neutrophils, share identical ligand-binding domains but have opposing signaling functions. Based on phylogenetic analyses of these receptors, we predicted that endogenous sialic acid-independent ligands should exist. An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory. The functional consequences of this interaction are also addressed in relation to a SIGLEC14 polymorphism found in humans. Our results demonstrate that an endogenous non-sialic acid-bearing molecule can be either a danger-associated or self-associated signal through paired Siglecs, and may explain seemingly contradictory prior reports on extracellular Hsp70 action. Twit Text FOAVip Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14 ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26459514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26459514 #FOAvip English Wikipedia <ref>{{Cite pmid|26459514 }}</ref> Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14 #MMPMID26459514 Fong JJ ; Sreedhara K ; Deng L ; Varki NM ; Angata T ; Liu Q ; Nizet V ; Varki A EMBO J 2015[Nov]; 34 (22 ): 2775-88 PMID26459514 show ga The intracellular chaperone heat-shock protein 70 (Hsp70) can be secreted from cells, but its extracellular role is unclear, as the protein has been reported to both activate and suppress the innate immune response. Potential immunomodulatory receptors on myelomonocytic lineage cells that bind extracellular Hsp70 are not well defined. Siglecs are Ig-superfamily lectins on mammalian leukocytes that recognize sialic acid-bearing glycans and thereby modulate immune responses. Siglec-5 and Siglec-14, expressed on monocytes and neutrophils, share identical ligand-binding domains but have opposing signaling functions. Based on phylogenetic analyses of these receptors, we predicted that endogenous sialic acid-independent ligands should exist. An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory. The functional consequences of this interaction are also addressed in relation to a SIGLEC14 polymorphism found in humans. Our results demonstrate that an endogenous non-sialic acid-bearing molecule can be either a danger-associated or self-associated signal through paired Siglecs, and may explain seemingly contradictory prior reports on extracellular Hsp70 action. |Antigens, CD/genetics/*immunology [MESH] |Antigens, Differentiation, Myelomonocytic/genetics/*immunology [MESH] |Cell Line, Tumor [MESH] |HEK293 Cells [MESH] |HSP70 Heat-Shock Proteins/genetics/*immunology [MESH] |Humans [MESH] |Inflammation/genetics/immunology/pathology [MESH] |Lectins/genetics/*immunology [MESH] |Monocytes/*immunology/pathology [MESH] |Receptors, Cell Surface/genetics/*immunology [MESH]Immunomodulatory activity of extracellular Hsp70 mediated via paired r(epmc).pdf DeepDyve Pubget Overpricing