Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26398682
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Gastroenterol
2015 ; 31
(6
): 449-55
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cross-talk between type 3 innate lymphoid cells and the gut microbiota in
inflammatory bowel disease
#MMPMID26398682
Buela KA
; Omenetti S
; Pizarro TT
Curr Opin Gastroenterol
2015[Nov]; 31
(6
): 449-55
PMID26398682
show ga
PURPOSE OF REVIEW: Innate lymphoid cells (ILCs) are a newly-identified population
of immune cells prevalent in, but not limited to, mucosal tissues that not only
play a significant role in immune homeostasis and host defense, but also in
disease pathogenesis. This review highlights the importance of type 3 ILCs
(ILC3s) and their interactions with the intestinal microflora, both in
maintaining gut health and in the development of inflammatory bowel disease
(IBD). RECENT FINDINGS: Distinct lineages of ILCs are defined based on the
presence of cell surface proteins, secretion of effector cytokines and expression
of master transcription factors that determine their differentiation and
inflammatory behavior. These ILC subgroups mirror corresponding CD4 T-cell
subsets, with which they share many phenotypic, morphologic and functional
attributes. ILC3s, in particular, through direct and indirect interactions with
the gut microbiota, have been identified to promote protection and maintenance of
epithelial integrity, as well as to regulate intestinal inflammation and
fibrosis, such as that observed in IBD. SUMMARY: Gut mucosal ILCs respond to
environmental cues, such as diet and microflora composition, which can shape
downstream immune function. As such, ILCs represent attractive targets for the
development of therapeutic modalities to maintain gut health and to potentially
treat IBD.