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10.1186/s12887-015-0537-y http://scihub22266oqcxt.onion/10.1186/s12887-015-0537-y C4682231!4682231 !26678681     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26678681 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Pediatr 2015 ; 15 (ä): 214 Nephropedia Template TP {{tp|p=26678681 |t=2015. The NeBoP score - a clinical prediction test for evaluation of children with Lyme Neuroborreliosis in Europe |pdf=|usr=}}{{26678681 }} gab.com Text The NeBoP score - a clinical prediction test for evaluation of children with Lyme Neuroborreliosis in Europe JO: BMC Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=26678681 #FOAvip BACKGROUND: The diagnosis of Lyme neuroborreliosis (LNB) in Europe is based on clinical symptoms and laboratory data, such as pleocytosis and anti-Borrelia antibodies in serum and CSF according to guidelines. However, the decision to start antibiotic treatment on admission cannot be based on Borrelia serology since results are not available at the time of lumbar puncture. Therefore, an early prediction test would be useful in clinical practice. The aim of the study was to develop and evaluate a clinical prediction test for children with LNB in a relevant European setting. METHOD: Clinical and laboratory data were collected retrospectively from a cohort of children being evaluated for LNB in Southeast Sweden. A clinical neuroborreliosis prediction test, the NeBoP score, was designed to differentiate between a high and a low risk of having LNB. The NeBoP score was then prospectively validated in a cohort of children being evaluated for LNB in Central and Southeast Sweden (n?=?190) and controls with other specific diagnoses (n?=?49). RESULTS: The sensitivity of the NeBoP score was 90 % (CI 95 %; 82-99 %) and the specificity was 90 % (CI 95 %; 85-96 %). Thus, the diagnostic accuracy (i.e. how the test correctly discriminates patients from controls) was 90 % and the area under the curve in a ROC analysis was 0.95. The positive predictive value (PPV) was 0.83 (CI 95 %; 0.75-0.93) and the negative predictive value (NPV) was 0.95 (CI 95 %; 0.90-0.99). CONCLUSION: The overall diagnostic performance of the NeBoP score is high (90 %) and the test is suggested to be useful for decision-making about early antibiotic treatment in children being evaluated for LNB in European Lyme endemic areas. Twit Text FOAVip The NeBoP score - a clinical prediction test for evaluation of children with Lyme Neuroborreliosis in Europe ????BMC Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=26678681 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26678681 #FOAvip English Wikipedia <ref>{{Cite pmid|26678681 }}</ref> The NeBoP score - a clinical prediction test for evaluation of children with Lyme Neuroborreliosis in Europe #MMPMID26678681 Skogman BH ; Sjöwall J ; Lindgren PE BMC Pediatr 2015[Dec]; 15 (ä): 214 PMID26678681 show ga BACKGROUND: The diagnosis of Lyme neuroborreliosis (LNB) in Europe is based on clinical symptoms and laboratory data, such as pleocytosis and anti-Borrelia antibodies in serum and CSF according to guidelines. However, the decision to start antibiotic treatment on admission cannot be based on Borrelia serology since results are not available at the time of lumbar puncture. Therefore, an early prediction test would be useful in clinical practice. The aim of the study was to develop and evaluate a clinical prediction test for children with LNB in a relevant European setting. METHOD: Clinical and laboratory data were collected retrospectively from a cohort of children being evaluated for LNB in Southeast Sweden. A clinical neuroborreliosis prediction test, the NeBoP score, was designed to differentiate between a high and a low risk of having LNB. The NeBoP score was then prospectively validated in a cohort of children being evaluated for LNB in Central and Southeast Sweden (n?=?190) and controls with other specific diagnoses (n?=?49). RESULTS: The sensitivity of the NeBoP score was 90 % (CI 95 %; 82-99 %) and the specificity was 90 % (CI 95 %; 85-96 %). Thus, the diagnostic accuracy (i.e. how the test correctly discriminates patients from controls) was 90 % and the area under the curve in a ROC analysis was 0.95. The positive predictive value (PPV) was 0.83 (CI 95 %; 0.75-0.93) and the negative predictive value (NPV) was 0.95 (CI 95 %; 0.90-0.99). CONCLUSION: The overall diagnostic performance of the NeBoP score is high (90 %) and the test is suggested to be useful for decision-making about early antibiotic treatment in children being evaluated for LNB in European Lyme endemic areas. |*Decision Support Techniques [MESH] |Adolescent [MESH] |Anti-Bacterial Agents/therapeutic use [MESH] |Child [MESH] |Child, Preschool [MESH] |Clinical Decision-Making [MESH] |Endemic Diseases [MESH] |Female [MESH] |Humans [MESH] |Infant [MESH] |Lyme Neuroborreliosis/*diagnosis/drug therapy [MESH] |Male [MESH] |Retrospective Studies [MESH] |Risk Assessment [MESH] |Sensitivity and Specificity [MESH] |Sweden [MESH]The NeBoP score - a clinical prediction test for evaluation of childre(epmc).pdf DeepDyve Pubget Overpricing