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10.1038/ncomms10072 http://scihub22266oqcxt.onion/10.1038/ncomms10072 C4682058!4682058 !26656453     free     free     free       Nat+Commun 2015 ; 6 (?): 10072 Nephropedia Template TP {{tp|p=26656453 |t=2015. Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis |pdf=|usr=}}{{26656453 }} gab.com Text Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26656453 #FOAvip TANK Binding Kinase 1 (TBK1) is a non-canonical I?B kinase that contributes to KRAS-driven lung cancer. Here we report that TBK1 plays essential roles in mammalian cell division. Specifically, levels of active phospho-TBK1 increase during mitosis and localize to centrosomes, mitotic spindles and midbody, and selective inhibition or silencing of TBK1 triggers defects in spindle assembly and prevents mitotic progression. TBK1 binds to the centrosomal protein CEP170 and to the mitotic apparatus protein NuMA, and both CEP170 and NuMA are TBK1 substrates. Further, TBK1 is necessary for CEP170 centrosomal localization and binding to the microtubule depolymerase Kif2b, and for NuMA binding to dynein. Finally, selective disruption of the TBK1-CEP170 complex augments microtubule stability and triggers defects in mitosis, suggesting that TBK1 functions as a mitotic kinase necessary for microtubule dynamics and mitosis. Twit Text FOAVip Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26656453 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26656453 #FOAvip English Wikipedia <ref>{{Cite pmid|26656453 }}</ref> Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis #MMPMID26656453 Pillai S ; Nguyen J ; Johnson J ; Haura E ; Coppola D ; Chellappan S Nat Commun 2015[Dec]; 6 (?): 10072 PMID26656453 show ga TANK Binding Kinase 1 (TBK1) is a non-canonical I?B kinase that contributes to KRAS-driven lung cancer. Here we report that TBK1 plays essential roles in mammalian cell division. Specifically, levels of active phospho-TBK1 increase during mitosis and localize to centrosomes, mitotic spindles and midbody, and selective inhibition or silencing of TBK1 triggers defects in spindle assembly and prevents mitotic progression. TBK1 binds to the centrosomal protein CEP170 and to the mitotic apparatus protein NuMA, and both CEP170 and NuMA are TBK1 substrates. Further, TBK1 is necessary for CEP170 centrosomal localization and binding to the microtubule depolymerase Kif2b, and for NuMA binding to dynein. Finally, selective disruption of the TBK1-CEP170 complex augments microtubule stability and triggers defects in mitosis, suggesting that TBK1 functions as a mitotic kinase necessary for microtubule dynamics and mitosis. |Cell Line [MESH] |Centrosome/*enzymology [MESH] |Gene Expression Regulation, Enzymologic/physiology [MESH] |Humans [MESH] |Microtubules/*physiology [MESH] |Mitosis/*physiology [MESH] |Protein Binding [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH]Tank binding kinase 1 is a centrosome-associated kinase necessary for (epmc).pdf DeepDyve Pubget Overpricing