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2015 ; 22
(3
): 25-32
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Parasitemia Induces High Plasma Levels of Interleukin-17 (IL-17) and Low Levels
of Interleukin-10 (IL-10) and Transforming Growth Factor-ß (TGF-ß) in Pregnant
Mice Infected with Malaria
#MMPMID26715893
Rahmah Z
; Sasmito SD
; Siswanto B
; Sardjono TW
; Fitri LE
Malays J Med Sci
2015[May]; 22
(3
): 25-32
PMID26715893
show ga
BACKGROUND: During pregnancy, the balanced dominance of the T helper17 response
shifts to a Th2 response that is characterised by the production of IL-10,
following the completion of the implantation process. Transforming growth
factor-? (TGF-?) expression is associated with the completion of trophoblast
invasion and placental growth. This study assessed the effect of malaria
infection on the levels of IL-17, IL-10, and TGF-? in the plasma of pregnant mice
with malaria. METHODS: Seventeen pregnant BALB/C mice were divided into two
groups: mice infected with Plasmodium berghei (treatment group) and uninfected
mice (control group). The mice were sacrificed on day 18 post-mating. Parasitemia
was measured by Giemsa staining. The levels of IL-17, IL-10, and TGF-? were
measured by ELISA. RESULTS: Using independent t test, the IL-17 levels in the
treatment group were higher than those in the control group (= = 0.040). The
IL-10 levels in the treatment group were lower than those in the control group (=
= 0.00). There was no significant difference in the TGF-? levels (= = 0.055)
between two groups. However, using SEM analysis the degree of parasitemia
decreased the plasma TGF-? levels (tcount = 5.148; ? ttable = 1.96). SEM analysis
showed that a high degree of parasitemia increased the IL-17 levels and decreased
the IL-10 and TGF-? levels. CONCLUSION: Malaria infection during pregnancy
interferes with the systemic balance by increasing the IL-17 levels and
decreasing the IL-10 and TGF-? levels.