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10.1080/21688370.2015.1081861 http://scihub22266oqcxt.onion/10.1080/21688370.2015.1081861 C4681290!4681290!26716074     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Tissue+Barriers 2015 ; 3 (4): ä Nephropedia Template TP {{tp|p=26716074|t=2015. Targeting renal epithelial channels for the control of insect vectors |pdf=|usr=}}{{26716074}} gab.com Text Targeting renal epithelial channels for the control of insect vectors JO: Tissue Barriers http://www.kidney.de/pget.php?&tw=1&pmid=26716074 #FOAvip Three small molecules were identified in high throughput screens that 1) block renal inward rectifier potassium (Kir) channels of Aedes aegypti expressed in HEK cells and Xenopus oocytes, 2) inhibit the secretion of KCl but not NaCl in isolated Malpighian tubules, and after injection into the hemolymph, 3) inhibit KCl excretion in vivo, and 4) render mosquitoes flightless or dead within 24h. Some mosquitoes had swollen abdomens at death consistent with renal failure. VU625, the most potent and promising small molecule for development as mosquitocide, inhibits AeKir1-mediated currents with an IC50 less than 100 nM. It is highly selective for AeKir1 over mammalian Kir channels, and it affects only 3 of 68 mammalian membrane proteins. These results document 1) renal failure as a new mode-of-action for mosquitocide development, 2) renal Kir channels as molecular target for inducing renal failure, and 3) the promise of the discovery and development of new species-specific insecticides. Twit Text FOAVip Targeting renal epithelial channels for the control of insect vectors ????Tissue Barriers http://www.kidney.de/pget.php?&tw=1&pmid=26716074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26716074 #FOAvip English Wikipedia <ref>{{Cite pmid|26716074}}</ref> Targeting renal epithelial channels for the control of insect vectors #MMPMID26716074 Beyenbach KW; Yu Y; Piermarini PM; Denton J Tissue Barriers 2015[Oct]; 3 (4): ä PMID26716074show ga Three small molecules were identified in high throughput screens that 1) block renal inward rectifier potassium (Kir) channels of Aedes aegypti expressed in HEK cells and Xenopus oocytes, 2) inhibit the secretion of KCl but not NaCl in isolated Malpighian tubules, and after injection into the hemolymph, 3) inhibit KCl excretion in vivo, and 4) render mosquitoes flightless or dead within 24h. Some mosquitoes had swollen abdomens at death consistent with renal failure. VU625, the most potent and promising small molecule for development as mosquitocide, inhibits AeKir1-mediated currents with an IC50 less than 100 nM. It is highly selective for AeKir1 over mammalian Kir channels, and it affects only 3 of 68 mammalian membrane proteins. These results document 1) renal failure as a new mode-of-action for mosquitocide development, 2) renal Kir channels as molecular target for inducing renal failure, and 3) the promise of the discovery and development of new species-specific insecticides. äTargeting renal epithelial channels for the control of insect vectors (epmc).pdf DeepDyve Pubget Overpricing