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2015 ; 5
(ä): 18112
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gab.com Text
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English Wikipedia
The global landscape of cognition: hierarchical aggregation as an organizational
principle of human cortical networks and functions
#MMPMID26669858
Taylor P
; Hobbs JN
; Burroni J
; Siegelmann HT
Sci Rep
2015[Dec]; 5
(ä): 18112
PMID26669858
show ga
Though widely hypothesized, limited evidence exists that human brain functions
organize in global gradients of abstraction starting from sensory cortical
inputs. Hierarchical representation is accepted in computational networks, and
tentatively in visual neuroscience, yet no direct holistic demonstrations exist
in vivo. Our methods developed network models enriched with tiered
directionality, by including input locations, a critical feature for localizing
representation in networks generally. Grouped primary sensory cortices defined
network inputs, displaying global connectivity to fused inputs. Depth-oriented
networks guided analyses of fMRI databases (~17,000 experiments;~1/4 of fMRI
literature). Formally, we tested whether network depth predicted localization of
abstract versus concrete behaviors over the whole set of studied brain regions.
For our results, new cortical graph metrics, termed network-depth, ranked all
databased cognitive function activations by network-depth. Thus, we objectively
sorted stratified landscapes of cognition, starting from grouped sensory inputs
in parallel, progressing deeper into cortex. This exposed escalating amalgamation
of function or abstraction with increasing network-depth, globally. Nearly 500
new participants confirmed our results. In conclusion, data-driven analyses
defined a hierarchically ordered connectome, revealing a related continuum of
cognitive function. Progressive functional abstraction over network depth may be
a fundamental feature of brains, and is observed in artificial networks.