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10.1186/s12864-015-2280-z http://scihub22266oqcxt.onion/10.1186/s12864-015-2280-z C4681139!4681139 !26673865     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26673865 &cmd=llinks): Failed to open stream: HTTP request failed! 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Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets |pdf=|usr=}}{{26673865 }} gab.com Text Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets JO: BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26673865 #FOAvip BACKGROUND: Comparison between multiple protein datasets requires the choice of an appropriate reference system and a number of variables to describe their differences. Here we introduce an innovative approach to discriminate multiple protein datasets (multiCM) and to measure enrichments in gene ontology terms (cleverGO) using semantic similarities. RESULTS: We illustrate the powerfulness of our approach by investigating the links between RNA-binding ability and other protein features, such as structural disorder and aggregation, in S. cerevisiae, C. elegans, M. musculus and H. sapiens. Our results are in striking agreement with available experimental evidence and unravel features that are key to understand the mechanisms regulating cellular homeostasis. CONCLUSIONS: In an intuitive way, multiCM and cleverGO provide accurate classifications of physico-chemical features and annotations of biological processes, molecular functions and cellular components, which is extremely useful for the discovery and characterization of new trends in protein datasets. The multiCM and cleverGO can be freely accessed on the Web at http://www.tartaglialab.com/cs_multi/submission and http://www.tartaglialab.com/GO_analyser/universal . Each of the pages contains links to the corresponding documentation and tutorial. Twit Text FOAVip Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets ????BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26673865 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26673865 #FOAvip English Wikipedia <ref>{{Cite pmid|26673865 }}</ref> Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets #MMPMID26673865 Klus P ; Ponti RD ; Livi CM ; Tartaglia GG BMC Genomics 2015[Dec]; 16 (ä): 1071 PMID26673865 show ga BACKGROUND: Comparison between multiple protein datasets requires the choice of an appropriate reference system and a number of variables to describe their differences. Here we introduce an innovative approach to discriminate multiple protein datasets (multiCM) and to measure enrichments in gene ontology terms (cleverGO) using semantic similarities. RESULTS: We illustrate the powerfulness of our approach by investigating the links between RNA-binding ability and other protein features, such as structural disorder and aggregation, in S. cerevisiae, C. elegans, M. musculus and H. sapiens. Our results are in striking agreement with available experimental evidence and unravel features that are key to understand the mechanisms regulating cellular homeostasis. CONCLUSIONS: In an intuitive way, multiCM and cleverGO provide accurate classifications of physico-chemical features and annotations of biological processes, molecular functions and cellular components, which is extremely useful for the discovery and characterization of new trends in protein datasets. The multiCM and cleverGO can be freely accessed on the Web at http://www.tartaglialab.com/cs_multi/submission and http://www.tartaglialab.com/GO_analyser/universal . Each of the pages contains links to the corresponding documentation and tutorial. |*Molecular Structure [MESH] |*Protein Aggregation, Pathological [MESH] |Algorithms [MESH] |Computational Biology/methods [MESH] |RNA-Binding Proteins/*chemistry/*metabolism [MESH] |Software [MESH] |Solubility [MESH]Protein aggregation, structural disorder and RNA-binding ability: a ne(epmc).pdf DeepDyve Pubget Overpricing