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10.1099/vir.0.000140 http://scihub22266oqcxt.onion/10.1099/vir.0.000140 C4681069!4681069!25872742     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2015 ; 96 (Pt 8): 2314-27 Nephropedia Template TP {{tp|p=25872742|t=2015. Subcapsular sinus macrophages limit acute gammaherpesvirus dissemination |pdf=|usr=}}{{25872742}} gab.com Text Subcapsular sinus macrophages limit acute gammaherpesvirus dissemination JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=25872742 #FOAvip Lymphocyte proliferation, mobility and longevity make them prime targets for virus infection. Myeloid cells that process and present environmental antigens to lymphocytes are consequently an important line of defence. Subcapsular sinus macrophages (SSMs) filter the afferent lymph and communicate with B-cells. How they interact with B-cell-tropic viruses is unknown. We analysed their encounter with murid herpesvirus-4 (MuHV-4), an experimentally accessible gammaherpesvirus related to Kaposi's sarcoma-associated herpesvirus. MuHV-4 disseminated via lymph nodes, and intranasally or subcutaneously inoculated virions readily infected SSMs. However, this infection was poorly productive. SSM depletion with clodronate-loaded liposomes or with diphtheria toxin in CD169?diphtheria toxin receptor transgenic mice increased B-cell infection and hastened virus spread to the spleen. Dendritic cells provided the main route to B-cells, and SSMs slowed host colonization, apparently by absorbing virions non-productively from the afferent lymph. Twit Text FOAVip Subcapsular sinus macrophages limit acute gammaherpesvirus dissemination ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=25872742 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25872742 #FOAvip English Wikipedia <ref>{{Cite pmid|25872742}}</ref> Subcapsular sinus macrophages limit acute gammaherpesvirus dissemination #MMPMID25872742 Frederico B; Chao B; Lawler C; May JS; Stevenson PG J Gen Virol 2015[Aug]; 96 (Pt 8): 2314-27 PMID25872742show ga Lymphocyte proliferation, mobility and longevity make them prime targets for virus infection. Myeloid cells that process and present environmental antigens to lymphocytes are consequently an important line of defence. Subcapsular sinus macrophages (SSMs) filter the afferent lymph and communicate with B-cells. How they interact with B-cell-tropic viruses is unknown. We analysed their encounter with murid herpesvirus-4 (MuHV-4), an experimentally accessible gammaherpesvirus related to Kaposi's sarcoma-associated herpesvirus. MuHV-4 disseminated via lymph nodes, and intranasally or subcutaneously inoculated virions readily infected SSMs. However, this infection was poorly productive. SSM depletion with clodronate-loaded liposomes or with diphtheria toxin in CD169?diphtheria toxin receptor transgenic mice increased B-cell infection and hastened virus spread to the spleen. Dendritic cells provided the main route to B-cells, and SSMs slowed host colonization, apparently by absorbing virions non-productively from the afferent lymph. äSubcapsular sinus macrophages limit acute gammaherpesvirus disseminati(epmc).pdf DeepDyve Pubget Overpricing