Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Immun+Ageing 2015 ; 12 (ä): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
End stage renal disease patients have a skewed T cell receptor V? repertoire #MMPMID26677394
Immun Ageing 2015[]; 12 (ä): ä PMID26677394show ga
Background: End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) V? repertoire is central to effective T-cell mediated immune responses to foreign antigens. In this study, the effect of ESRD on TCR V? repertoire was assessed. Results: A higher proportion of ESRD patients (68.9 %) had a skewed TCR V? repertoire compared to age and cytomegalovirus (CMV) ? IgG serostatus matched healthy individuals (31.4 %, P?0.001). Age, CMV serostatus and ESRD were independently associated with an increase in shifting of the TCR V? repertoire. More differentiated CD8+ T cells were observed in young ESRD patients with a shifted TCR V? repertoire. CD31-expressing naive T cells and relative telomere length of T cells were not significantly related to TCR V? skewing. Conclusions: ESRD significantly skewed the TCR V? repertoire particularly in the elderly population, which may contribute to the uremia-associated defect in T-cell mediated immunity. Electronic supplementary material: The online version of this article (doi:10.1186/s12979-015-0055-7) contains supplementary material, which is available to authorized users.