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10.1016/j.celrep.2015.10.058 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.10.058 C4681001!4681001 !26655905     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26655905 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2015 ; 13 (9 ): 1909-1921 Nephropedia Template TP {{tp|p=26655905 |t=2015. Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways |pdf=|usr=}}{{26655905 }} gab.com Text Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26655905 #FOAvip Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity, but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer. However, Dectin-1 deletion exacerbates liver fibro-inflammatory disease and accelerates hepatocarcinogenesis. Mechanistically, we found that Dectin-1 protects against chronic liver disease by suppressing TLR4 signaling in hepatic inflammatory and stellate cells. Accordingly, Dectin-1(-/-) mice exhibited augmented cytokine production and reduced survival in lipopolysaccharide (LPS)-mediated sepsis, whereas Dectin-1 activation was protective. We showed that Dectin-1 inhibits TLR4 signaling by mitigating TLR4 and CD14 expression, which are regulated by Dectin-1-dependent macrophage colony stimulating factor (M-CSF) expression. Our study suggests that Dectin-1 is an attractive target for experimental therapeutics in hepatic fibrosis and neoplastic transformation. More broadly, our work deciphers critical cross-talk between pattern recognition receptors and implicates a role for Dectin-1 in suppression of sterile inflammation, inflammation-induced oncogenesis, and LPS-mediated sepsis. Twit Text FOAVip Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26655905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26655905 #FOAvip English Wikipedia <ref>{{Cite pmid|26655905 }}</ref> Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways #MMPMID26655905 Seifert L ; Deutsch M ; Alothman S ; Alqunaibit D ; Werba G ; Pansari M ; Pergamo M ; Ochi A ; Torres-Hernandez A ; Levie E ; Tippens D ; Greco SH ; Tiwari S ; Ly NNG ; Eisenthal A ; van Heerden E ; Avanzi A ; Barilla R ; Zambirinis CP ; Rendon M ; Daley D ; Pachter HL ; Hajdu C ; Miller G Cell Rep 2015[Dec]; 13 (9 ): 1909-1921 PMID26655905 show ga Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity, but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer. However, Dectin-1 deletion exacerbates liver fibro-inflammatory disease and accelerates hepatocarcinogenesis. Mechanistically, we found that Dectin-1 protects against chronic liver disease by suppressing TLR4 signaling in hepatic inflammatory and stellate cells. Accordingly, Dectin-1(-/-) mice exhibited augmented cytokine production and reduced survival in lipopolysaccharide (LPS)-mediated sepsis, whereas Dectin-1 activation was protective. We showed that Dectin-1 inhibits TLR4 signaling by mitigating TLR4 and CD14 expression, which are regulated by Dectin-1-dependent macrophage colony stimulating factor (M-CSF) expression. Our study suggests that Dectin-1 is an attractive target for experimental therapeutics in hepatic fibrosis and neoplastic transformation. More broadly, our work deciphers critical cross-talk between pattern recognition receptors and implicates a role for Dectin-1 in suppression of sterile inflammation, inflammation-induced oncogenesis, and LPS-mediated sepsis. |Animals [MESH] |Cell Transformation, Neoplastic/drug effects [MESH] |Cells, Cultured [MESH] |Chemokine CCL2/blood [MESH] |Cytokines/metabolism [MESH] |Diethylnitrosamine/toxicity [MESH] |Hepatocytes/cytology/metabolism [MESH] |Humans [MESH] |Inflammation [MESH] |Lectins, C-Type/deficiency/genetics/*metabolism [MESH] |Lipopolysaccharide Receptors/metabolism [MESH] |Lipopolysaccharides/toxicity [MESH] |Liver Cirrhosis/chemically induced/metabolism/*pathology [MESH] |Liver Neoplasms/chemically induced/metabolism/*pathology [MESH] |Liver/metabolism/pathology [MESH] |Macrophage Colony-Stimulating Factor/genetics/metabolism/pharmacology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Recombinant Proteins/biosynthesis/isolation & purification/pharmacology [MESH] |Sepsis/etiology [MESH] |Signal Transduction/drug effects [MESH] |Thioacetamide/toxicity [MESH] |Toll-Like Receptor 4/antagonists & inhibitors/*metabolism [MESH]Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppre(epmc).pdf DeepDyve Pubget Overpricing