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10.1038/srep18316 http://scihub22266oqcxt.onion/10.1038/srep18316 C4680939!4680939!26671074     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26671074&cmd=llinks): Failed to open stream: HTTP request failed! 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Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2Akita diabetic mouse |pdf=|usr=}}{{26671074}} gab.com Text Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2Akita diabetic mouse JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26671074 #FOAvip Current therapies that target vascular endothelial growth factor (VEGF) have become a mainstream therapy for the management of diabetic macular oedema. The treatment involves monthly repeated intravitreal injections of VEGF inhibitors. VEGF is an important growth factor for many retinal cells, including different types of neurons. In this study, we investigated the adverse effect of multiple intravitreal anti-VEGF injections (200?ng/?l/eye anti-mouse VEGF164, once every 2 weeks totalling 5?6 injections) to retinal neurons in Ins2Akita diabetic mice. Funduscopic examination revealed the development of cotton wool spot-like lesions in anti-VEGF treated Ins2Akita mice after 5 injections. Histological investigation showed focal swellings of retinal nerve fibres with neurofilament disruption. Furthermore, anti-VEGF-treated Ins2Akita mice exhibited impaired electroretinographic responses, characterized by reduced scotopic a- and b-wave and oscillatory potentials. Immunofluorescent staining revealed impairment of photoreceptors, disruptions of synaptic structures and loss of amacrine and retinal ganglion cells in anti-VEGF treated Ins2Akita mice. Anti-VEGF-treated WT mice also presented mild amacrine and ganglion cell death, but no overt abnormalities in photoreceptors and synaptic structures. At the vascular level, exacerbated albumin leakage was observed in anti-VEGF injected diabetic mice. Our results suggest that sustained intraocular VEGF neutralization induces retinal neurodegeneration and vascular damage in the diabetic eye. Twit Text FOAVip Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2Akita diabetic mouse ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26671074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26671074 #FOAvip English Wikipedia <ref>{{Cite pmid|26671074}}</ref> Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2Akita diabetic mouse #MMPMID26671074 Hombrebueno JR; Ali IH; Xu H; Chen M Sci Rep 2015[]; 5 (ä): ä PMID26671074show ga Current therapies that target vascular endothelial growth factor (VEGF) have become a mainstream therapy for the management of diabetic macular oedema. The treatment involves monthly repeated intravitreal injections of VEGF inhibitors. VEGF is an important growth factor for many retinal cells, including different types of neurons. In this study, we investigated the adverse effect of multiple intravitreal anti-VEGF injections (200?ng/?l/eye anti-mouse VEGF164, once every 2 weeks totalling 5?6 injections) to retinal neurons in Ins2Akita diabetic mice. Funduscopic examination revealed the development of cotton wool spot-like lesions in anti-VEGF treated Ins2Akita mice after 5 injections. Histological investigation showed focal swellings of retinal nerve fibres with neurofilament disruption. Furthermore, anti-VEGF-treated Ins2Akita mice exhibited impaired electroretinographic responses, characterized by reduced scotopic a- and b-wave and oscillatory potentials. Immunofluorescent staining revealed impairment of photoreceptors, disruptions of synaptic structures and loss of amacrine and retinal ganglion cells in anti-VEGF treated Ins2Akita mice. Anti-VEGF-treated WT mice also presented mild amacrine and ganglion cell death, but no overt abnormalities in photoreceptors and synaptic structures. At the vascular level, exacerbated albumin leakage was observed in anti-VEGF injected diabetic mice. Our results suggest that sustained intraocular VEGF neutralization induces retinal neurodegeneration and vascular damage in the diabetic eye. äSustained intraocular VEGF neutralization results in retinal neurodege(epmc).pdf DeepDyve Pubget Overpricing