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10.1038/srep18035 http://scihub22266oqcxt.onion/10.1038/srep18035 C4680857!4680857!26669264     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26669264|t=2015. Rat and human STINGs profile similarly towards anticancer/antiviral compounds |pdf=|usr=}}{{26669264}} gab.com Text Rat and human STINGs profile similarly towards anticancer/antiviral compounds JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26669264 #FOAvip Cyclic dinucleotides (CDNs) and antitumor/antiviral agents (DMXAA and CMA) trigger STING-dependent innate immunity activation. Accumulative evidences have showed that DMXAA and CMA selectively activate mouse, but not human STING signaling. The mechanism underlying this species selectivity remains poorly understood. In this report, we have shown that human and rat STINGs display more similar signaling profiles toward DMXAA and CMA than that of human and mouse STINGs, suggesting that rat is more suitable for preclinical testing of STING-targeted drugs. We have also determined the crystal structures of both apo rat STING and its complex with cyclic GMP-AMP with 2?5? and 3?5? phosphodiester linkage (2?3?-cGAMP), a human endogenous CDN. Structure-guided biochemical analysis also revealed the functional importance of the connecting loop (A140-N152) between membrane and cytosolic domains in STING activation. Taken together, these findings reveal that rat STING is more closely related to human STING in terms of substrate preference, serving as a foundation for the development of STING-targeted drugs. Twit Text FOAVip Rat and human STINGs profile similarly towards anticancer/antiviral compounds ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26669264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26669264 #FOAvip English Wikipedia <ref>{{Cite pmid|26669264}}</ref> Rat and human STINGs profile similarly towards anticancer/antiviral compounds #MMPMID26669264 Zhang H; Han MJ; Tao J; Ye ZY; Du XX; Deng MJ; Zhang XY; Li LF; Jiang ZF; Su XD Sci Rep 2015[]; 5 (ä): ä PMID26669264show ga Cyclic dinucleotides (CDNs) and antitumor/antiviral agents (DMXAA and CMA) trigger STING-dependent innate immunity activation. Accumulative evidences have showed that DMXAA and CMA selectively activate mouse, but not human STING signaling. The mechanism underlying this species selectivity remains poorly understood. In this report, we have shown that human and rat STINGs display more similar signaling profiles toward DMXAA and CMA than that of human and mouse STINGs, suggesting that rat is more suitable for preclinical testing of STING-targeted drugs. We have also determined the crystal structures of both apo rat STING and its complex with cyclic GMP-AMP with 2?5? and 3?5? phosphodiester linkage (2?3?-cGAMP), a human endogenous CDN. Structure-guided biochemical analysis also revealed the functional importance of the connecting loop (A140-N152) between membrane and cytosolic domains in STING activation. Taken together, these findings reveal that rat STING is more closely related to human STING in terms of substrate preference, serving as a foundation for the development of STING-targeted drugs. äRat and human STINGs profile similarly towards anticancer/antiviral co(epmc).pdf DeepDyve Pubget Overpricing