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http://scihub22266oqcxt.onion/ C4680550!4680550!26722605     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Clin+Exp+Pathol 2015 ; 8 (10): 13759-63 Nephropedia Template TP {{tp|p=26722605|t=2015. Correlation between BOLD-MRI and HIF expression level in renal carcinoma |pdf=|usr=}}{{26722605}} gab.com Text Correlation between BOLD-MRI and HIF expression level in renal carcinoma JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26722605 #FOAvip Occupying about 2%~3% of all malignant tumors, renal carcinoma is the most common primary cancer in kidney. The oxidative level of tumor cells is of vital role for optimizing treatment plan, evaluating efficacy and predicting prognosis. This study thus investigated the R2* value in mouse renal carcinoma model and the correlation between tumor hypoxia and expression level of hypoxia inducible factor-1 (HIF-1). A total of 20 BALB/C nude mice (4~6 weeks old) were inoculated with human ACHN renal carcinoma cells to generate renal cancer model. After the tumor diameter reached 0.5 cm, all animals were examined by BOLD-MRI, both under normal inhalation (R2a*) and carbogen treatment (R2b*). The alternation of R2* values (?R2*=R2a* - R2b*) was calculated. Mice were then sacrificed for Immunohistochemical (IHC) staining targeting HIF-1? and HIF-2?. The positive score of HIF was then analyzed for its correlation with R2* value. In 18 mice finished both experiments, Pearson correlation analysis revealed significant negative correlation between R2a* and ?R2* (r=-0.48, P<0.05) and positive relationship between ?R2* and HIF-2? (r=0.38, P<0.05). HIF-1? level, however, did not correlated with tumor R* values. The positive correlation between ?R2* and HIF-2?, but not HIF-1?, suggested potential role of combined BOLD-MRI technique and HIF-1? staining in clinical diagnosis of renal carcinoma. HIF-2? may work as biological marker for renal cancer. Twit Text FOAVip Correlation between BOLD-MRI and HIF expression level in renal carcinoma ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26722605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26722605 #FOAvip English Wikipedia <ref>{{Cite pmid|26722605}}</ref> Correlation between BOLD-MRI and HIF expression level in renal carcinoma #MMPMID26722605 Li D; Wang X; Wang S; Cheng J Int J Clin Exp Pathol 2015[]; 8 (10): 13759-63 PMID26722605show ga Occupying about 2%~3% of all malignant tumors, renal carcinoma is the most common primary cancer in kidney. The oxidative level of tumor cells is of vital role for optimizing treatment plan, evaluating efficacy and predicting prognosis. This study thus investigated the R2* value in mouse renal carcinoma model and the correlation between tumor hypoxia and expression level of hypoxia inducible factor-1 (HIF-1). A total of 20 BALB/C nude mice (4~6 weeks old) were inoculated with human ACHN renal carcinoma cells to generate renal cancer model. After the tumor diameter reached 0.5 cm, all animals were examined by BOLD-MRI, both under normal inhalation (R2a*) and carbogen treatment (R2b*). The alternation of R2* values (?R2*=R2a* - R2b*) was calculated. Mice were then sacrificed for Immunohistochemical (IHC) staining targeting HIF-1? and HIF-2?. The positive score of HIF was then analyzed for its correlation with R2* value. In 18 mice finished both experiments, Pearson correlation analysis revealed significant negative correlation between R2a* and ?R2* (r=-0.48, P<0.05) and positive relationship between ?R2* and HIF-2? (r=0.38, P<0.05). HIF-1? level, however, did not correlated with tumor R* values. The positive correlation between ?R2* and HIF-2?, but not HIF-1?, suggested potential role of combined BOLD-MRI technique and HIF-1? staining in clinical diagnosis of renal carcinoma. HIF-2? may work as biological marker for renal cancer. äCorrelation between BOLD-MRI and HIF expression level in renal carcino(epmc).pdf DeepDyve Pubget Overpricing