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CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by
activating Wnt/PCP signaling
#MMPMID26722469
Yang XM
; You HY
; Li Q
; Ma H
; Wang YH
; Zhang YL
; Zhu L
; Nie HZ
; Qin WX
; Zhang ZG
; Li J
Int J Clin Exp Pathol
2015[]; 8
(10
): 12793-801
PMID26722469
show ga
Collagen triple helix repeats containing 1 (CTHRC1) participates in vascular
remodeling, bone formation, and developmental morphogenesis. Recently, CTHRC1 has
been found up-regulated in many solid tumors and contributes to tumorigenesis,
but its role in the progression of human colorectal cancer (CRC), remains
unclear. In this study, CTHRC1 expression in human CRC cell lines was evaluated
by quantitative real-time PCR and immunoblot analyses. The role of CTHRC1 in CRC
cell proliferation and extracellular matrix invasion in vitro was analyzed by
gene over-expression and recombinant protein. Reporter luciferase assay was used
to reveal key relevant signaling pathways involved in CRC cells. The results show
that CTHRC1 is secreted both by colorectal epithelia cells and stromal
fibroblasts. Recombinant CTHRC1 promotes CRC cell migration and invasion
dose-dependently. CTHRC1 overexpression promotes CRC cell migration, invasion and
proliferation in vitro. Wnt/PCP signaling but not Wnt/catenin signaling was
activates by CTHRC1 in CRC cells. Together, CTHRC1 promotes CRC cell
proliferation, migration and invasion in vitro, which is possibly mediated by
activating Wnt/PCP pathway.
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