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http://scihub22266oqcxt.onion/ C4680384!4680384 !26722439     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26722439 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Clin+Exp+Pathol 2015 ; 8 (10 ): 12517-24 Nephropedia Template TP {{tp|p=26722439 |t=2015. Tubeimoside-1 inhibits the growth and invasion of colorectal cancer cells through the Wnt/?-catenin signaling pathway |pdf=|usr=}}{{26722439 }} gab.com Text Tubeimoside-1 inhibits the growth and invasion of colorectal cancer cells through the Wnt/ -catenin signaling pathway JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26722439 #FOAvip Tubeimoside-1 (TBMS1) is considered to have anti-tumor properties. However, the role of TBMS1 on human colorectal cancer (CRC) is still unclear. Therefore, in this study, we investigated the role of TBMS1 on human CRC and explored the underlying mechanism. The cell proliferation of CRC cells was detected by MTT assay. Cell migration and invasion were assessed by Boyden chamber assay, and the involvement of molecular mechanisms was examined by western blot. In this study, we found that TBMS1 inhibited the proliferation, migration/invasion of CRC cells, and it reduced ?-catenin expression in CRC cells. Furthermore, overexpression of ?-catenin rescued TBMS1-induced proliferation and invasion inhibition, and knockdown of ?-catenin potentiated TBMS1-induced proliferation and invasion inhibition. Taken together, our results demonstrate that TBMS1 inhibited CRC cell proliferation and invasion via suppressing the Wnt/?-catenin signaling pathway. Therefore, TBMS1 may represent a chemopreventive and/or therapeutic agent in the prevention of CRC. Twit Text FOAVip Tubeimoside-1 inhibits the growth and invasion of colorectal cancer cells through the Wnt/ -catenin signaling pathway ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26722439 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26722439 #FOAvip English Wikipedia <ref>{{Cite pmid|26722439 }}</ref> Tubeimoside-1 inhibits the growth and invasion of colorectal cancer cells through the Wnt/?-catenin signaling pathway #MMPMID26722439 Bian Q ; Liu P ; Gu J ; Song B Int J Clin Exp Pathol 2015[]; 8 (10 ): 12517-24 PMID26722439 show ga Tubeimoside-1 (TBMS1) is considered to have anti-tumor properties. However, the role of TBMS1 on human colorectal cancer (CRC) is still unclear. Therefore, in this study, we investigated the role of TBMS1 on human CRC and explored the underlying mechanism. The cell proliferation of CRC cells was detected by MTT assay. Cell migration and invasion were assessed by Boyden chamber assay, and the involvement of molecular mechanisms was examined by western blot. In this study, we found that TBMS1 inhibited the proliferation, migration/invasion of CRC cells, and it reduced ?-catenin expression in CRC cells. Furthermore, overexpression of ?-catenin rescued TBMS1-induced proliferation and invasion inhibition, and knockdown of ?-catenin potentiated TBMS1-induced proliferation and invasion inhibition. Taken together, our results demonstrate that TBMS1 inhibited CRC cell proliferation and invasion via suppressing the Wnt/?-catenin signaling pathway. Therefore, TBMS1 may represent a chemopreventive and/or therapeutic agent in the prevention of CRC. |Antineoplastic Agents, Phytogenic/*pharmacology [MESH] |Blotting, Western [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Colorectal Neoplasms/metabolism/*pathology [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Neoplasm Invasiveness/pathology [MESH] |RNA, Small Interfering [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Saponins/*pharmacology [MESH] |Transfection [MESH] |Triterpenes/*pharmacology [MESH]Tubeimoside-1 inhibits the growth and invasion of colorectal cancer ce(epmc).pdf DeepDyve Pubget Overpricing