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10.1155/2015/356040 http://scihub22266oqcxt.onion/10.1155/2015/356040 C4680115!4680115 !26713003     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26713003 &cmd=llinks): Failed to open stream: HTTP request failed! 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Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis |pdf=|usr=}}{{26713003 }} gab.com Text Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26713003 #FOAvip OBJECTIVE: To expand upon the role of iguratimod (T-614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal. METHODS: In this trial, 74 patients were randomized into iguratimod-treated (group A) and control (broup B) group for a 24-week treatment period. In the subsequent 28 weeks, both groups were given iguratimod. Frequencies of Th1, Th17, Tfh, and Treg were quantified using flow cytometry, and serum cytokines were detected by enzyme-linked immunosorbent assay. mRNA expression of cytokines and transcriptional factor were quantified by RT-PCR. The composite Disease Activity Score, erythrocyte sedimentation rate, and C-reactive protein were assessed at each visit. RESULT: The clinical scores demonstrated effective suppression of disease after treatment with iguratimod. In addition, iguratimod downregulated Th1, Th17-type response and upregulated Treg. Furthermore, the levels of Th1, Th17, and Tfh associated inflammatory cytokines and transcription factors were reduced after treatment with iguratimod, while the levels of Treg associated cytokines and transcription factors were increased. Twit Text FOAVip Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26713003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26713003 #FOAvip English Wikipedia <ref>{{Cite pmid|26713003 }}</ref> Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis #MMPMID26713003 Xu Y ; Zhu Q ; Song J ; Liu H ; Miao Y ; Yang F ; Wang F ; Cheng W ; Xi Y ; Niu X ; He D ; Chen G Mediators Inflamm 2015[]; 2015 (ä): 356040 PMID26713003 show ga OBJECTIVE: To expand upon the role of iguratimod (T-614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal. METHODS: In this trial, 74 patients were randomized into iguratimod-treated (group A) and control (broup B) group for a 24-week treatment period. In the subsequent 28 weeks, both groups were given iguratimod. Frequencies of Th1, Th17, Tfh, and Treg were quantified using flow cytometry, and serum cytokines were detected by enzyme-linked immunosorbent assay. mRNA expression of cytokines and transcriptional factor were quantified by RT-PCR. The composite Disease Activity Score, erythrocyte sedimentation rate, and C-reactive protein were assessed at each visit. RESULT: The clinical scores demonstrated effective suppression of disease after treatment with iguratimod. In addition, iguratimod downregulated Th1, Th17-type response and upregulated Treg. Furthermore, the levels of Th1, Th17, and Tfh associated inflammatory cytokines and transcription factors were reduced after treatment with iguratimod, while the levels of Treg associated cytokines and transcription factors were increased. |Adult [MESH] |Arthritis, Rheumatoid/*drug therapy/immunology [MESH] |Chromones/*therapeutic use [MESH] |Cytokines/*antagonists & inhibitors [MESH] |Female [MESH] |Humans [MESH] |Middle Aged [MESH] |Sulfonamides/*therapeutic use [MESH] |T-Lymphocytes, Regulatory/drug effects [MESH] |Th1 Cells/*drug effects [MESH]Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhib(epmc).pdf DeepDyve Pubget Overpricing