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2015 ; 32
(12
): 1177-91
Nephropedia Template TP
gab.com Text
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English Wikipedia
Management of Chronic Kidney Disease: The Relationship Between Serum Uric Acid
and Development of Nephropathy
#MMPMID26650815
Mende C
Adv Ther
2015[Dec]; 32
(12
): 1177-91
PMID26650815
show ga
Chronic kidney disease (CKD) is increasingly recognized as a global health
problem, and new and effective strategies are needed for the management of this
condition. Recently, there has been renewed interest in the relationship between
serum uric acid (SUA) levels and CKD, and several recent trials have demonstrated
a possible link between SUA and the development and/or progression of CKD in
patients with and without diabetes. The identification of key urate transporters
such as urate transporter 1 and glucose transporter 9 has provided not only
insights into the pathophysiology of hyperuricemia, but also possible links to
other processes, such as glucose homeostasis. The renewed interest in the role of
SUA in CKD has coincided with the development of sodium glucose co-transporter 2
inhibitors for the treatment of diabetes. In addition to improving glycemic
control, these agents, acting via the kidneys in an insulin-independent manner,
have also been shown to reduce SUA levels and potentially improve some measures
of renal function. This review will discuss the role of uric acid in CKD
treatment, and how SUA-lowering therapies may prevent or delay the progression of
CKD. FUNDING: Janssen Scientific Affairs.
|Blood Glucose
[MESH]
|Diabetes Mellitus/blood
[MESH]
|Disease Progression
[MESH]
|Glucose Transport Proteins, Facilitative/metabolism
[MESH]