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10.1016/j.mod.2015.08.001 http://scihub22266oqcxt.onion/10.1016/j.mod.2015.08.001 C4679655!4679655 !26248207     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26248207 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mech+Dev 2015 ; 138 Pt 3 (ä): 328-35 Nephropedia Template TP {{tp|p=26248207 |t=2015. The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish |pdf=|usr=}}{{26248207 }} gab.com Text The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish JO: Mech Dev http://www.kidney.de/pget.php?&tw=1&pmid=26248207 #FOAvip The zebrafish pronephric tubule consists of proximal and distal segments and a collecting duct. The proximal segment is subdivided into the neck, proximal convoluted tubule (PCT) and proximal straight tubule (PST) segments. The distal segment consists of the distal-early (DE) and distal-late (DL) segments. How the proximal and distal segments develop along the anteroposterior axis is poorly understood. Here we show that knockdown of taz in zebrafish caused shortening and a significant reduction in the number of principal cells of the PST-DE segment, and proximalization of the pronephric tubule in 24 hpf embryos. RA treatment expanded the pronephric proximal domain in normal embryos as in taz morphants, an effect that was further enhanced upon exposure of taz morphants to RA. The early pronephric defects in 24 hpf taz morphants led to the failure of anterior pronephric tubule migration and convolution, and to PCT dilation and cyst formation in older embryos. In situ hybridization showed weak and transient expression of taz at the bud stage in the intermediate mesoderm, the source of pronephric progenitors. The present findings show that Taz is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating RA signaling in the pronephric progenitor field in the intermediate mesoderm. Twit Text FOAVip The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish ????Mech Dev http://www.kidney.de/pget.php?&tw=1&pmid=26248207 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26248207 #FOAvip English Wikipedia <ref>{{Cite pmid|26248207 }}</ref> The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish #MMPMID26248207 Zhang J ; Yuan S ; Vasilyev A ; Amin Arnaout M Mech Dev 2015[Nov]; 138 Pt 3 (ä): 328-35 PMID26248207 show ga The zebrafish pronephric tubule consists of proximal and distal segments and a collecting duct. The proximal segment is subdivided into the neck, proximal convoluted tubule (PCT) and proximal straight tubule (PST) segments. The distal segment consists of the distal-early (DE) and distal-late (DL) segments. How the proximal and distal segments develop along the anteroposterior axis is poorly understood. Here we show that knockdown of taz in zebrafish caused shortening and a significant reduction in the number of principal cells of the PST-DE segment, and proximalization of the pronephric tubule in 24 hpf embryos. RA treatment expanded the pronephric proximal domain in normal embryos as in taz morphants, an effect that was further enhanced upon exposure of taz morphants to RA. The early pronephric defects in 24 hpf taz morphants led to the failure of anterior pronephric tubule migration and convolution, and to PCT dilation and cyst formation in older embryos. In situ hybridization showed weak and transient expression of taz at the bud stage in the intermediate mesoderm, the source of pronephric progenitors. The present findings show that Taz is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating RA signaling in the pronephric progenitor field in the intermediate mesoderm. |Animals [MESH] |Animals, Genetically Modified [MESH] |Body Patterning/drug effects/genetics/physiology [MESH] |Cell Count [MESH] |Gene Expression Regulation, Developmental [MESH] |Gene Knockdown Techniques [MESH] |Intracellular Signaling Peptides and Proteins/antagonists & inhibitors/genetics/*physiology [MESH] |Kidney Tubules/cytology/*embryology/metabolism [MESH] |Mesoderm/cytology/embryology/metabolism [MESH] |Pronephros/cytology/*embryology/metabolism [MESH] |Transcriptional Coactivator with PDZ-Binding Motif Proteins [MESH] |Tretinoin/metabolism/pharmacology [MESH] |Zebrafish Proteins/antagonists & inhibitors/genetics/*physiology [MESH]The transcriptional coactivator Taz regulates proximodistal patterning(epmc).pdf DeepDyve Pubget Overpricing