Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.it.2015.07.005 http://scihub22266oqcxt.onion/10.1016/j.it.2015.07.005 C4679291!4679291!26277449     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2015 ; 36 (9): 519-26 Nephropedia Template TP {{tp|p=26277449|t=2015. Super-enhancers: Asset management in immune cell genomes |pdf=|usr=}}{{26277449}} gab.com Text Super-enhancers: Asset management in immune cell genomes JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26277449 #FOAvip Super-enhancers (SEs) are regions of the genome consisting of clusters of regulatory elements bound with very high amounts of transcription factors, and this architecture appears to be the hallmark of genes and noncoding RNAs linked with cell identity. Recent studies have identified SEs in CD4+ T cells and have further linked these regions to SNPs associated with immune-mediated disorders, pointing to an important role for these structures in the T cell differentiation and function. Here we review the features that define SEs, and discuss their function within the broader understanding of the mechanisms that define immune cell identity and function. We propose that SEs present crucial regulatory hubs, coordinating intrinsic and extrinsic differentiation signals, and argue that delineating these regions will provide important insight into the factors and mechanisms that define immune cell identity. Twit Text FOAVip Super-enhancers: Asset management in immune cell genomes ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26277449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26277449 #FOAvip English Wikipedia <ref>{{Cite pmid|26277449}}</ref> Super-enhancers: Asset management in immune cell genomes #MMPMID26277449 Witte S; O?Shea JJ; Vahedi G Trends Immunol 2015[Sep]; 36 (9): 519-26 PMID26277449show ga Super-enhancers (SEs) are regions of the genome consisting of clusters of regulatory elements bound with very high amounts of transcription factors, and this architecture appears to be the hallmark of genes and noncoding RNAs linked with cell identity. Recent studies have identified SEs in CD4+ T cells and have further linked these regions to SNPs associated with immune-mediated disorders, pointing to an important role for these structures in the T cell differentiation and function. Here we review the features that define SEs, and discuss their function within the broader understanding of the mechanisms that define immune cell identity and function. We propose that SEs present crucial regulatory hubs, coordinating intrinsic and extrinsic differentiation signals, and argue that delineating these regions will provide important insight into the factors and mechanisms that define immune cell identity. äSuper-enhancers: Asset management in immune cell genomes (epmc).pdf DeepDyve Pubget Overpricing