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10.1038/srep18147

http://scihub22266oqcxt.onion/10.1038/srep18147
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C4678862!4678862!26667846
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suck abstract from ncbi


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pmid26667846      Sci+Rep 2015 ; 5 (ä): ä
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  • A Large-scale Survey of CRF55_01B from Men-Who-Have-Sex-with-Men in China: implying the Evolutionary History and Public Health Impact #MMPMID26667846
  • Han X; Takebe Y; Zhang W; An M; Zhao B; Hu Q; Xu J; Wu H; Wu J; Lu L; Chen X; Liang S; Wang Z; Yan H; Fu J; Cai W; Zhuang M; Liao C; Shang H
  • Sci Rep 2015[]; 5 (ä): ä PMID26667846show ga
  • The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China, involving the co-circulation of several different lineages of HIV-1 strains, including subtype B and CRF01_AE. This expansion has created conditions that facilitate the generation of new recombinant strains. A molecular epidemiologic survey among MSM in 11 provinces/cities around China was conducted from 2008 to 2013. Based on pol nucleotide sequences, a total of 19 strains (1.95%) belonged to the CRF55_01B were identified from 975 MSM in 7 provinces, with the prevalence range from 1.5% to 12.5%. Near full length genome (NFLG) sequences from six epidemiologically-unlinked MSM were amplified for analyzing evolutionary history, an identical genome structure composed of CRF01_AE and subtype B with four unique recombination breakpoints in the pol region were identified. Bayesian molecular clock analyses for both CRF01_AE and B segments indicated that the estimated time of the most recent common ancestors of CRF55_01B was around the year 2000. Our study found CRF55_01B has spread throughout the most provinces with high HIV-1 prevalence and highlights the importance of continual surveillance of dynamic changes in HIV-1 strains, the emergence of new recombinants, and the need for implementing effective prevention measures specifically targeting the MSM population in China.
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