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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Rep
2015 ; 5
(ä): 18147
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A Large-scale Survey of CRF55_01B from Men-Who-Have-Sex-with-Men in China:
implying the Evolutionary History and Public Health Impact
#MMPMID26667846
Han X
; Takebe Y
; Zhang W
; An M
; Zhao B
; Hu Q
; Xu J
; Wu H
; Wu J
; Lu L
; Chen X
; Liang S
; Wang Z
; Yan H
; Fu J
; Cai W
; Zhuang M
; Liao C
; Shang H
Sci Rep
2015[Dec]; 5
(ä): 18147
PMID26667846
show ga
The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in
China, involving the co-circulation of several different lineages of HIV-1
strains, including subtype B and CRF01_AE. This expansion has created conditions
that facilitate the generation of new recombinant strains. A molecular
epidemiologic survey among MSM in 11 provinces/cities around China was conducted
from 2008 to 2013. Based on pol nucleotide sequences, a total of 19 strains
(1.95%) belonged to the CRF55_01B were identified from 975 MSM in 7 provinces,
with the prevalence range from 1.5% to 12.5%. Near full length genome (NFLG)
sequences from six epidemiologically-unlinked MSM were amplified for analyzing
evolutionary history, an identical genome structure composed of CRF01_AE and
subtype B with four unique recombination breakpoints in the pol region were
identified. Bayesian molecular clock analyses for both CRF01_AE and B segments
indicated that the estimated time of the most recent common ancestors of
CRF55_01B was around the year 2000. Our study found CRF55_01B has spread
throughout the most provinces with high HIV-1 prevalence and highlights the
importance of continual surveillance of dynamic changes in HIV-1 strains, the
emergence of new recombinants, and the need for implementing effective prevention
measures specifically targeting the MSM population in China.