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10.1186/s40169-015-0076-z http://scihub22266oqcxt.onion/10.1186/s40169-015-0076-z C4678131!4678131!26668061     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Med 2015 ; 4 (ä): ä Nephropedia Template TP {{tp|p=26668061|t=2015. A shared mechanism of muscle wasting in cancer and Huntington?s disease |pdf=|usr=}}{{26668061}} gab.com Text A shared mechanism of muscle wasting in cancer and Huntington s disease JO: Clin Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=26668061 #FOAvip Skeletal muscle loss and dysfunction in aging and chronic diseases is one of the major causes of mortality in patients, and is relevant for a wide variety of diseases such as neurodegeneration and cancer. Muscle loss is accompanied by changes in gene expression and metabolism that lead to contractile impairment and likely affect whole-body metabolism and function. The changes may be caused by inactivity, inflammation, age-related factors or unbalanced nutrition. Although links with skeletal muscle loss have been found in diseases with disparate aetiologies, for example both in Huntington?s disease (HD) and cancer cachexia, the outcome is a similar impairment and mortality. This short commentary aims to summarize recent achievements in the identification of common mechanisms leading to the skeletal muscle wasting syndrome seen in diseases as different as cancer and HD. The latter is the most common hereditary neurodegenerative disorder and muscle wasting is an important component of its pathology. In addition, possible therapeutic strategies for anti-cachectic treatment will be also discussed in the light of their translation into possible therapeutic approaches for HD. Twit Text FOAVip A shared mechanism of muscle wasting in cancer and Huntington s disease ????Clin Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=26668061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26668061 #FOAvip English Wikipedia <ref>{{Cite pmid|26668061}}</ref> A shared mechanism of muscle wasting in cancer and Huntington?s disease #MMPMID26668061 Mielcarek M; Isalan M Clin Transl Med 2015[]; 4 (ä): ä PMID26668061show ga Skeletal muscle loss and dysfunction in aging and chronic diseases is one of the major causes of mortality in patients, and is relevant for a wide variety of diseases such as neurodegeneration and cancer. Muscle loss is accompanied by changes in gene expression and metabolism that lead to contractile impairment and likely affect whole-body metabolism and function. The changes may be caused by inactivity, inflammation, age-related factors or unbalanced nutrition. Although links with skeletal muscle loss have been found in diseases with disparate aetiologies, for example both in Huntington?s disease (HD) and cancer cachexia, the outcome is a similar impairment and mortality. This short commentary aims to summarize recent achievements in the identification of common mechanisms leading to the skeletal muscle wasting syndrome seen in diseases as different as cancer and HD. The latter is the most common hereditary neurodegenerative disorder and muscle wasting is an important component of its pathology. In addition, possible therapeutic strategies for anti-cachectic treatment will be also discussed in the light of their translation into possible therapeutic approaches for HD. äA shared mechanism of muscle wasting in cancer and Huntington?s diseas(epmc).pdf DeepDyve Pubget Overpricing