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10.1091/mbc.E15-09-0671

http://scihub22266oqcxt.onion/10.1091/mbc.E15-09-0671
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C4678025!4678025!26490120
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suck abstract from ncbi


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pmid26490120      Mol+Biol+Cell 2015 ; 26 (25): 4700-17
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  • Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion #MMPMID26490120
  • Parchure A; Vyas N; Ferguson C; Parton RG; Mayor S
  • Mol Biol Cell 2015[Dec]; 26 (25): 4700-17 PMID26490120show ga
  • Hedgehog (Hh)-containing exovesicles are mediators of long-range signaling in Drosophila wing imaginal discs. ESCRT-dependent multivesicular body (MVB) biogenesis is essential for generating Hh exovesicles. Oligomerization of Hh at the cell surface is necessary for its endocytic delivery to MVBs and therefore is required for its release as exovesicles.
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