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10.1126/science.aaa0986 http://scihub22266oqcxt.onion/10.1126/science.aaa0986 C4677687!4677687!25635099     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 347 (6221): 548-51 Nephropedia Template TP {{tp|p=25635099|t=2015. Replication-transcription switch in human mitochondria |pdf=|usr=}}{{25635099}} gab.com Text Replication-transcription switch in human mitochondria JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25635099 #FOAvip Coordinated replication and expression of mitochondrial genome is critical for metabolically active cells during various stages of development. However, it is not known whether replication and transcription can occur simultaneously without interfering with each other and whether mtDNA copy number can be regulated by the transcription machinery. We found that interaction of human transcription elongation factor, TEFM with mitochondrial RNA polymerase (mtRNAP) and nascent transcript prevents generation of replication primers and increases transcription processivity thereby serving as a molecular switch between replication and transcription, which appear to be mutually exclusive processes in mitochondria. TEFM may allow mitochondria to increase transcription rates and, as consequence, respiration and ATP production without the need to replicate mtDNA, which has been observed during spermatogenesis and early stages of embryogenesis. Twit Text FOAVip Replication-transcription switch in human mitochondria ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25635099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25635099 #FOAvip English Wikipedia <ref>{{Cite pmid|25635099}}</ref> Replication-transcription switch in human mitochondria #MMPMID25635099 Agaronyan K; Morozov YI; Anikin M; Temiakov D Science 2015[Jan]; 347 (6221): 548-51 PMID25635099show ga Coordinated replication and expression of mitochondrial genome is critical for metabolically active cells during various stages of development. However, it is not known whether replication and transcription can occur simultaneously without interfering with each other and whether mtDNA copy number can be regulated by the transcription machinery. We found that interaction of human transcription elongation factor, TEFM with mitochondrial RNA polymerase (mtRNAP) and nascent transcript prevents generation of replication primers and increases transcription processivity thereby serving as a molecular switch between replication and transcription, which appear to be mutually exclusive processes in mitochondria. TEFM may allow mitochondria to increase transcription rates and, as consequence, respiration and ATP production without the need to replicate mtDNA, which has been observed during spermatogenesis and early stages of embryogenesis. äReplication-transcription switch in human mitochondria (epmc).pdf DeepDyve Pubget Overpricing