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10.1126/scitranslmed.aaa8419 http://scihub22266oqcxt.onion/10.1126/scitranslmed.aaa8419 C4677674!4677674!25904745     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2015 ; 7 (284): 284re3 Nephropedia Template TP {{tp|p=25904745|t=2015. Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans |pdf=|usr=}}{{25904745}} gab.com Text Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=25904745 #FOAvip Hyperammonemia syndrome is a fatal complication affecting immunosuppressed patients. Frequently refractory to treatment, it is characterized by progressive elevations in serum ammonia of unknown etiology, ultimately leading to cerebral edema and death. In mammals, ammonia produced during amino acid metabolism is primarily cleared through the hepatic production of urea, which is eliminated in the kidney. Ureaplasma species, commensals of the urogenital tract, are Mollicutes dependent on urea hydrolysis to ammonia and carbon dioxide for energy production. We hypothesized that systemic infection with Ureaplasma species might pose a unique challenge to human ammonia metabolism by liberating free ammonia resulting in the hyperammonemia syndrome. We used polymerase chain reaction, specialized culture, and molecular resistance profiling to identify systemic Ureaplasma infection in lung transplant recipients with hyperammonemia syndrome, but did not detect it in any lung transplant recipients with normal ammonia concentrations. Administration of Ureaplasma-directed antimicrobials to patients with hyperammonemia syndrome resulted in biochemical and clinical resolution of the disorder. Relapse in one patient was accompanied by recurrent Ureaplasma bacteremia with antimicrobial resistance. Our results provide evidence supporting a causal relationship between Ureaplasma infection and hyperammonemia, suggesting a need to test for this organism and provide empiric antimicrobial treatment while awaiting microbiological confirmation. Twit Text FOAVip Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=25904745 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25904745 #FOAvip English Wikipedia <ref>{{Cite pmid|25904745}}</ref> Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans #MMPMID25904745 Bharat A; Cunningham SA; Scott Budinger GR; Kreisel D; DeWet CJ; Gelman AE; Waites K; Crabb D; Xiao L; Bhorade S; Ambalavanan N; Dilling DF; Lowery EM; Astor T; Hachem R; Krupnick AS; DeCamp MM; Ison MG; Patel R Sci Transl Med 2015[Apr]; 7 (284): 284re3 PMID25904745show ga Hyperammonemia syndrome is a fatal complication affecting immunosuppressed patients. Frequently refractory to treatment, it is characterized by progressive elevations in serum ammonia of unknown etiology, ultimately leading to cerebral edema and death. In mammals, ammonia produced during amino acid metabolism is primarily cleared through the hepatic production of urea, which is eliminated in the kidney. Ureaplasma species, commensals of the urogenital tract, are Mollicutes dependent on urea hydrolysis to ammonia and carbon dioxide for energy production. We hypothesized that systemic infection with Ureaplasma species might pose a unique challenge to human ammonia metabolism by liberating free ammonia resulting in the hyperammonemia syndrome. We used polymerase chain reaction, specialized culture, and molecular resistance profiling to identify systemic Ureaplasma infection in lung transplant recipients with hyperammonemia syndrome, but did not detect it in any lung transplant recipients with normal ammonia concentrations. Administration of Ureaplasma-directed antimicrobials to patients with hyperammonemia syndrome resulted in biochemical and clinical resolution of the disorder. Relapse in one patient was accompanied by recurrent Ureaplasma bacteremia with antimicrobial resistance. Our results provide evidence supporting a causal relationship between Ureaplasma infection and hyperammonemia, suggesting a need to test for this organism and provide empiric antimicrobial treatment while awaiting microbiological confirmation. äDisseminated Ureaplasma infection as a cause of fatal hyperammonemia i(epmc).pdf DeepDyve Pubget Overpricing