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10.4274/jcrpe.2067 http://scihub22266oqcxt.onion/10.4274/jcrpe.2067 C4677562!4677562!26831561     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26831561&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Res+Pediatr+Endocrinol 2015 ; 7 (3): 242-8 Nephropedia Template TP {{tp|p=26831561|t=2015. Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene |pdf=|usr=}}{{26831561}} gab.com Text Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene JO: J Clin Res Pediatr Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26831561 #FOAvip Testotoxicosis is a rare disorder which presents as isosexual peripheral precocious puberty in males. Despite the pattern of autosomal dominant inheritance, sporadic cases also may occur. Due to activating mutation in luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene, early virilization and advancement in bone age are common with increased serum testosterone levels above adult ranges, despite low LH and follicular-stimulating hormone (FSH) levels. There are different treatment regimens, such as combination of bicalutamide (antiandrogen agent) and a third-generation aromatase inhibitor, that are reported to be well-tolerated and successful in slowing bone age advancement and preventing progression of virilization. We report here two patients who presented with peripheral precocious puberty and an activating mutation in the LHCGR gene: one with a family history and previously determined mutation and the other without family history and with a novel mutation (c.830G>T). Combination of bicalutamide+anastrozole was ineffective in slowing pubertal progression and bone age. Short-term results were better with ketoconazole. Twit Text FOAVip Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene ????J Clin Res Pediatr Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26831561 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26831561 #FOAvip English Wikipedia <ref>{{Cite pmid|26831561}}</ref> Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene #MMPMID26831561 Özcab? B; Tahmiscio?lu Bucak F; Ceylaner S; Özcan R; Büyükünal C; Ercan O; Tüysüz B; Evliyao?lu O J Clin Res Pediatr Endocrinol 2015[Sep]; 7 (3): 242-8 PMID26831561show ga Testotoxicosis is a rare disorder which presents as isosexual peripheral precocious puberty in males. Despite the pattern of autosomal dominant inheritance, sporadic cases also may occur. Due to activating mutation in luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene, early virilization and advancement in bone age are common with increased serum testosterone levels above adult ranges, despite low LH and follicular-stimulating hormone (FSH) levels. There are different treatment regimens, such as combination of bicalutamide (antiandrogen agent) and a third-generation aromatase inhibitor, that are reported to be well-tolerated and successful in slowing bone age advancement and preventing progression of virilization. We report here two patients who presented with peripheral precocious puberty and an activating mutation in the LHCGR gene: one with a family history and previously determined mutation and the other without family history and with a novel mutation (c.830G>T). Combination of bicalutamide+anastrozole was ineffective in slowing pubertal progression and bone age. Short-term results were better with ketoconazole. äTestotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCG(epmc).pdf DeepDyve Pubget Overpricing