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10.1038/srep18314 http://scihub22266oqcxt.onion/10.1038/srep18314 C4677317!4677317 !26658818     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26658818 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 18314 Nephropedia Template TP {{tp|p=26658818 |t=2015. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro |pdf=|usr=}}{{26658818 }} gab.com Text Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26658818 #FOAvip Madecassoside (MA), a triterpenoid saponin isolated from C. asitica, exerts various pharmacological activity including antioxidative and antinflammatory. Doxorubicin (DOX), a common chemotherapeutic drug, has been reported to induce numerous toxic side effects including renal-toxicity. We hypothesized that MA administration may decrease renal-toxicity caused by DOX. In this study, we investigated this hypothesis by introducing MA and DOX into the culture of Human Proximal Tubule Cells HK-2 and mice model. Our in vivo study demonstrated that MA (12?mg/kg), treatment for two weeks attenuated DOX-induced renal injury via protecting renal function, recovering antioxidant enzyme activity, inhibiting Bax, p-ERK1/2, NF-?B p65, iNOS expression and increasing Bcl-2 expression. Similar findings were obtained in our in vitro studies with treatment of DOX and/or MA. Further studies with application of iNOS inhibitor and ERK1/2 kinase inhibitor indicated that the inhibitory effects of MA on DOX-induced apoptosis and inflammation might be mediated by the suppression of the activation of cleaved caspase-3, ERK1/2 pathways, NF-?B p65 and NO production. These results suggest that MA is a promising protective agent for DOX-induced renal toxicity and can be a potential candidate to protect against renal toxicity in DOX-treated cancer patients. Twit Text FOAVip Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26658818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26658818 #FOAvip English Wikipedia <ref>{{Cite pmid|26658818 }}</ref> Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro #MMPMID26658818 Su Z ; Ye J ; Qin Z ; Ding X Sci Rep 2015[Dec]; 5 (ä): 18314 PMID26658818 show ga Madecassoside (MA), a triterpenoid saponin isolated from C. asitica, exerts various pharmacological activity including antioxidative and antinflammatory. Doxorubicin (DOX), a common chemotherapeutic drug, has been reported to induce numerous toxic side effects including renal-toxicity. We hypothesized that MA administration may decrease renal-toxicity caused by DOX. In this study, we investigated this hypothesis by introducing MA and DOX into the culture of Human Proximal Tubule Cells HK-2 and mice model. Our in vivo study demonstrated that MA (12?mg/kg), treatment for two weeks attenuated DOX-induced renal injury via protecting renal function, recovering antioxidant enzyme activity, inhibiting Bax, p-ERK1/2, NF-?B p65, iNOS expression and increasing Bcl-2 expression. Similar findings were obtained in our in vitro studies with treatment of DOX and/or MA. Further studies with application of iNOS inhibitor and ERK1/2 kinase inhibitor indicated that the inhibitory effects of MA on DOX-induced apoptosis and inflammation might be mediated by the suppression of the activation of cleaved caspase-3, ERK1/2 pathways, NF-?B p65 and NO production. These results suggest that MA is a promising protective agent for DOX-induced renal toxicity and can be a potential candidate to protect against renal toxicity in DOX-treated cancer patients. |Animals [MESH] |Antibiotics, Antineoplastic/*adverse effects [MESH] |Antioxidants/metabolism [MESH] |Apoptosis/drug effects [MESH] |Body Weight/drug effects [MESH] |Cell Line [MESH] |Cell Survival/drug effects [MESH] |Doxorubicin/*adverse effects [MESH] |Kidney Function Tests [MESH] |Kidney/*drug effects/metabolism/pathology/physiopathology [MESH] |MAP Kinase Signaling System/drug effects [MESH] |Male [MESH] |Mice [MESH] |NF-kappa B/metabolism [MESH] |Nephritis/etiology/metabolism/pathology [MESH] |Nitric Oxide/metabolism [MESH] |Protective Agents/chemistry/*pharmacology [MESH]Protective effects of madecassoside against Doxorubicin induced nephro(epmc).pdf DeepDyve Pubget Overpricing