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10.1155/2016/1958174 http://scihub22266oqcxt.onion/10.1155/2016/1958174 C4677237!4677237!26697129     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oxid+Med+Cell+Longev 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=26697129|t=2016. The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance |pdf=|usr=}}{{26697129}} gab.com Text The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26697129 #FOAvip The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes such as heme oxygenase 1 (HO-1). Nrf2 and HO-1 are frequently upregulated in different types of tumours and correlate with tumour progression, aggressiveness, resistance to therapy, and poor prognosis. This review focuses on the Nrf2/HO-1 stress response mechanism as a promising target for anticancer treatment which is able to overcome resistance to therapies. Twit Text FOAVip The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26697129 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26697129 #FOAvip English Wikipedia <ref>{{Cite pmid|26697129}}</ref> The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance #MMPMID26697129 Furfaro AL; Traverso N; Domenicotti C; Piras S; Moretta L; Marinari UM; Pronzato MA; Nitti M Oxid Med Cell Longev 2016[]; 2016 (ä): ä PMID26697129show ga The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes such as heme oxygenase 1 (HO-1). Nrf2 and HO-1 are frequently upregulated in different types of tumours and correlate with tumour progression, aggressiveness, resistance to therapy, and poor prognosis. This review focuses on the Nrf2/HO-1 stress response mechanism as a promising target for anticancer treatment which is able to overcome resistance to therapies. äThe Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance (epmc).pdf DeepDyve Pubget Overpricing