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10.1155/2016/1716341

http://scihub22266oqcxt.onion/10.1155/2016/1716341
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C4677234!4677234!26697128
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suck abstract from ncbi


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pmid26697128      Oxid+Med+Cell+Longev 2016 ; 2016 (ä): ä
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  • Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy #MMPMID26697128
  • Lyakhovich A; Lleonart ME
  • Oxid Med Cell Longev 2016[]; 2016 (ä): ä PMID26697128show ga
  • Cancer stem cells (CSCs) are highly resistant to conventional chemo- and radiotherapeutic regimes. Therefore, the multiple drug resistance (MDR) of cancer is most likely due to the resistance of CSCs. Such resistance can be attributed to some bypassing pathways including detoxification mechanisms of reactive oxygen and nitrogen species (RO/NS) formation or enhanced autophagy. Unlike in normal cells, where RO/NS concentration is maintained at certain threshold required for signal transduction or immune response mechanisms, CSCs may develop alternative pathways to diminish RO/NS levels leading to cancer survival. In this minireview, we will focus on elaborated mechanisms developed by CSCs to attenuate high RO/NS levels. Gaining a better insight into the mechanisms of stem cell resistance to chemo- or radiotherapy may lead to new therapeutic targets thus serving for better anticancer strategies.
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