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10.1155/2016/5346327 http://scihub22266oqcxt.onion/10.1155/2016/5346327 C4677232!4677232 !26697136     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26697136 &cmd=llinks): Failed to open stream: HTTP request failed! 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Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia |pdf=|usr=}}{{26697136 }} gab.com Text Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26697136 #FOAvip Maternal physiological hypercholesterolemia occurs during pregnancy, ensuring normal fetal development. In some cases, the maternal plasma cholesterol level increases to above this physiological range, leading to maternal supraphysiological hypercholesterolemia (MSPH). This condition results in endothelial dysfunction and atherosclerosis in the fetal and placental vasculature. The fetal and placental endothelial dysfunction is related to alterations in the L-arginine/nitric oxide (NO) pathway and the arginase/urea pathway and results in reduced NO production. The level of tetrahydrobiopterin (BH4), a cofactor for endothelial NO synthase (eNOS), is reduced in nonpregnant women who have hypercholesterolemia, which favors the generation of the superoxide anion rather than NO (from eNOS), causing endothelial dysfunction. However, it is unknown whether MSPH is associated with changes in the level or metabolism of BH4; as a result, eNOS function is not well understood. This review summarizes the available information on the potential link between MSPH and BH4 in causing human fetoplacental vascular endothelial dysfunction, which may be crucial for understanding the deleterious effects of MSPH on fetal growth and development. Twit Text FOAVip Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26697136 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26697136 #FOAvip English Wikipedia <ref>{{Cite pmid|26697136 }}</ref> Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia #MMPMID26697136 Leiva A ; Fuenzalida B ; Westermeier F ; Toledo F ; Salomón C ; Gutiérrez J ; Sanhueza C ; Pardo F ; Sobrevia L Oxid Med Cell Longev 2015[]; 2015 (ä): 5346327 PMID26697136 show ga Maternal physiological hypercholesterolemia occurs during pregnancy, ensuring normal fetal development. In some cases, the maternal plasma cholesterol level increases to above this physiological range, leading to maternal supraphysiological hypercholesterolemia (MSPH). This condition results in endothelial dysfunction and atherosclerosis in the fetal and placental vasculature. The fetal and placental endothelial dysfunction is related to alterations in the L-arginine/nitric oxide (NO) pathway and the arginase/urea pathway and results in reduced NO production. The level of tetrahydrobiopterin (BH4), a cofactor for endothelial NO synthase (eNOS), is reduced in nonpregnant women who have hypercholesterolemia, which favors the generation of the superoxide anion rather than NO (from eNOS), causing endothelial dysfunction. However, it is unknown whether MSPH is associated with changes in the level or metabolism of BH4; as a result, eNOS function is not well understood. This review summarizes the available information on the potential link between MSPH and BH4 in causing human fetoplacental vascular endothelial dysfunction, which may be crucial for understanding the deleterious effects of MSPH on fetal growth and development. |Animals [MESH] |Arginine/metabolism [MESH] |Biopterins/*analogs & derivatives/metabolism [MESH] |Borohydrides/metabolism [MESH] |Cholesterol/blood [MESH] |Endothelium, Vascular/*metabolism [MESH] |Female [MESH] |Humans [MESH] |Hypercholesterolemia/metabolism/*pathology [MESH] |Nitric Oxide Synthase Type III/metabolism [MESH] |Nitric Oxide/metabolism [MESH]Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunct(epmc).pdf DeepDyve Pubget Overpricing