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10.1155/2015/801546

http://scihub22266oqcxt.onion/10.1155/2015/801546
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C4677222!4677222!26696755
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suck abstract from ncbi


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pmid26696755      Mediators+Inflamm 2015 ; 2015 (ä): ä
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  • The Function and Roles of ADAMTS-7 in Inflammatory Diseases #MMPMID26696755
  • Zhang Y; Lin J; Wei F
  • Mediators Inflamm 2015[]; 2015 (ä): ä PMID26696755show ga
  • The ADAMTS proteinases are a group of multidomain and secreted metalloproteinases containing the thrombospondin motifs. ADAMTS-7 is a member of ADAMTS family and plays a crucial role in the pathogenesis of arthritis. Overexpression of ADAMTS-7 gene promotes the breakdown of cartilage oligomeric matrix protein (COMP) matrix and accelerates the progression of both surgically induced osteoarthritis and collagen-induced arthritis. Moreover, ADAMTS-7 and tumor necrosis factor-? (TNF-?) form a positive feedback loop in osteoarthritis. More significantly, granulin-epithelin precursor, a growth factor has important roles in bone development and bone-associated diseases, disturbs the interaction between ADAMTS-7 and COMP, and prevents COMP degradation. This review is based on our results and provides an overview of current knowledge of ADAMTS-7, including its structure, function, gene regulation, and inflammatory diseases involvement.
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