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2015 ; 3
(12
): 988-92
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English Wikipedia
Sarcoma-associated sarcoid reaction: Report of cutaneous sarcoid reaction in a
patient with liposarcoma
#MMPMID26677448
Beutler BD
; Cohen PR
World J Clin Cases
2015[Dec]; 3
(12
): 988-92
PMID26677448
show ga
Sarcoidosis is a systemic inflammatory condition in which noncaseating
epithelioid cell granulomas appear within one or several body sites. Sarcoid
reaction (also referred to as sarcoidal or sarcoid-like reaction) occurs in
patients who do not fulfill the diagnostic criteria for systemic sarcoidosis but
present with similar clinical and histological features. As sarcoma-associated
sarcoid reactions are rare, we describe the features of sarcoid reaction that
developed in a man with liposarcoma and summarize reports of other oncology
patients with sarcoma-associated sarcoid reactions. A 68-year-old man with
retroperitoneal liposarcoma presented for evaluation of erythematous dermal
plaques on his left leg. Microscopic examination of a tissue specimen revealed
multiple epithelioid granulomas in the superficial and mid-reticular dermis.
Correlation of the clinical presentation and histopathologic findings established
a diagnosis of liposarcoma-associated cutaneous sarcoid reaction. Sarcoid
reactions have been described in only seven individuals with sarcoma, including
two patients with leiomyosarcoma and one patient with either carcinosarcoma,
Kaposi sarcoma, liposarcoma, malignant peripheral nerve sheath tumor,
rhabdosarcoma, or synovial sarcoma. Sarcoidal granulomas most commonly develop
within the locoregional draining lymph nodes. Sarcoid reactions may also affect
other organs, such as the lungs, skin, and spleen.