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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Proteomics 2015 ; 2015 (ä): ä Nephropedia Template TP
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Human Urine Proteomics: Analytical Techniques and Clinical Applications in Renal Diseases #MMPMID26693351
Kalantari S; Jafari A; Moradpoor R; Ghasemi E; Khalkhal E
Int J Proteomics 2015[]; 2015 (ä): ä PMID26693351show ga
Urine has been in the center of attention among scientists of clinical proteomics in the past decade, because it is valuable source of proteins and peptides with a relative stable composition and easy to collect in large and repeated quantities with a noninvasive procedure. In this review, we discuss technical aspects of urinary proteomics in detail, including sample preparation, proteomic technologies, and their advantage and disadvantages. Several recent experiments are presented which applied urinary proteome for biomarker discovery in renal diseases including diabetic nephropathy, immunoglobulin A (IgA) nephropathy, focal segmental glomerulosclerosis, lupus nephritis, membranous nephropathy, and acute kidney injury. In addition, several available databases in urinary proteomics are also briefly introduced.