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10.1002/eji.201545532 http://scihub22266oqcxt.onion/10.1002/eji.201545532 C4676762!4676762!26300525     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2015 ; 45 (11): 3045-51 Nephropedia Template TP {{tp|p=26300525|t=2015. Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells |pdf=|usr=}}{{26300525}} gab.com Text Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26300525 #FOAvip Invariant natural killer T (iNKT) cells recognize glycolipids as antigens and diversify into NKT1 (IFN-?), NKT2 (IL-4), and NKT17 (IL-17) functional subsets while developing in the thymus. Mechanisms that govern the balance between these functional subsets are poorly understood due partly to the lack of distinguishing surface markers. Here we identified the heparan sulfate proteoglycan syndecan-1 (sdc1) as a specific marker of naïve thymic NKT17 cells and that sdc1 deficiency significantly increased thymic NKT17 cells at the expense of NKT1 cells, leading to impaired iNKT cell-derived IFN-?, both in vitro and in vivo. Using surface expression of sdc1 to identify NKT17 cells, we confirmed differential tissue localization and interstrain variability of NKT17 cells and uncovered that NKT17 cells expressed high TCR?, preferentially use V?8, and display high sensitivity to ?-GalCer than to CD3/CD28 stimulation. These findings provide a novel non-invasive simple method for identification and viable sorting of naïve NKT17 cells from unmanipulated mice and suggest that sdc1 expression negatively regulates homeostasis iNKT cells. In addition, they lay the groundwork for investigating the mechanisms by which sdc1 regulates NKT17 cells. Twit Text FOAVip Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26300525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26300525 #FOAvip English Wikipedia <ref>{{Cite pmid|26300525}}</ref> Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells #MMPMID26300525 Dai H; Rahman A; Saxena A; Jaiswal A; Majithia R; Mohamood A; Ramirez L; Noel S; Rabb H; Jie C; Hamad ARA Eur J Immunol 2015[Nov]; 45 (11): 3045-51 PMID26300525show ga Invariant natural killer T (iNKT) cells recognize glycolipids as antigens and diversify into NKT1 (IFN-?), NKT2 (IL-4), and NKT17 (IL-17) functional subsets while developing in the thymus. Mechanisms that govern the balance between these functional subsets are poorly understood due partly to the lack of distinguishing surface markers. Here we identified the heparan sulfate proteoglycan syndecan-1 (sdc1) as a specific marker of naïve thymic NKT17 cells and that sdc1 deficiency significantly increased thymic NKT17 cells at the expense of NKT1 cells, leading to impaired iNKT cell-derived IFN-?, both in vitro and in vivo. Using surface expression of sdc1 to identify NKT17 cells, we confirmed differential tissue localization and interstrain variability of NKT17 cells and uncovered that NKT17 cells expressed high TCR?, preferentially use V?8, and display high sensitivity to ?-GalCer than to CD3/CD28 stimulation. These findings provide a novel non-invasive simple method for identification and viable sorting of naïve NKT17 cells from unmanipulated mice and suggest that sdc1 expression negatively regulates homeostasis iNKT cells. In addition, they lay the groundwork for investigating the mechanisms by which sdc1 regulates NKT17 cells. äSyndecan-1 identifies and controls the frequency of IL-17-producing na(epmc).pdf DeepDyve Pubget Overpricing