Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric
Premalignant and Malignant Lesions
#MMPMID26668797
Lee SK
Clin Endosc
2015[Nov]; 48
(6
): 511-5
PMID26668797
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Confocal laser endomicroscopy (CLE) is a new technology enabling endoscopists to
visualize tissue at the cellular level. CLE has the fundamental potential to
provide a histologic diagnosis, and may theoretically replace or reduce the need
for performing biopsy for histology. The clinical benefits of CLE are more
obvious in esophageal disease, including Barrett's esophagus. Currently, this
technology has been adapted to the diagnosis and surveillance of Barrett's
esophagus and related neoplasia. Standard white light endoscopy is the primary
tool for gastric cancer screening. Currently, the only method available to
precisely diagnose these lesions is upper endoscopy with an appropriate biopsy. A
recent study showed that CLE could characterize dysplasia or cancer and identify
the risk factors for gastric cancer, such as intestinal metaplasia and the
presence of Helicobacter pylori in vivo, although fewer studies on CLE were
performed on the stomach than on Barrett's esophagus and other esophageal
diseases. However, the application of CLE to routine clinical endoscopy continues
to be refined. This review focused on the usefulness and future prospects of CLE
for gastric premalignant and malignant lesions.
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