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2015 ; 2
(3
): 81-8
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Early detection of cardiotoxicity by 2D and 3D deformation imaging in patients
receiving chemotherapy
#MMPMID26693341
Tarr A
; Stoebe S
; Tuennemann J
; Baka Z
; Pfeiffer D
; Varga A
; Hagendorff A
Echo Res Pract
2015[Sep]; 2
(3
): 81-8
PMID26693341
show ga
The aim of the present study was to find out whether early cardiac changes in
patients receiving chemotherapy can be detected by the conventional and
deformation parameters of 2D and 3D echocardiography. Twenty-five healthy
subjects with normal regional left ventricular function (group 1) and 25 patients
receiving chemotherapy (group 2) underwent 2D and 3D transthoracic
echocardiography (Toshiba Artida Medical System). All patients (group 2) were
examined before and during cardiotoxic chemotherapy at a 3-month follow-up. Left
ventricular volumes, ejection fraction, muscle mass, global longitudinal, global
radial, global circumferential strain, and rotation were analyzed with 2D and 3D
echocardiography, while twist and time-to-peak-intervals were analyzed with 3D
echocardiography. For left ventricular volumes and muscle mass, no significant
differences were seen between the two study groups (P<0.05). According to our
results, myocardial dysfunction induced by cardiotoxic chemotherapy can be
detected by 2D global radial strain. Detecting myocardial dysfunction by global
longitudinal and circumferential strain requires more than 3 months follow-up.
Changes in rotation, twist or time-to-peak intervals could not be verified at the
3-month follow-up in the present study. 2D global radial strain seems to be the
most sensitive and robust parameter to detect early myocardial damage during
chemotherapy. 3D echocardiography is not yet an established method to detect
myocardial damage in clinical practice due to lower spatial and temporal
resolution.