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10.1186/s12935-015-0265-2 http://scihub22266oqcxt.onion/10.1186/s12935-015-0265-2 C4676109!4676109 !26692820     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26692820 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26692820 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Cell+Int 2015 ; 15 (ä): 114 Nephropedia Template TP {{tp|p=26692820 |t=2015. ESC reverses epithelial mesenchymal transition induced by transforming growth factor-? via inhibition of Smad signal pathway in HepG2 liver cancer cells |pdf=|usr=}}{{26692820 }} gab.com Text ESC reverses epithelial mesenchymal transition induced by transforming growth factor- via inhibition of Smad signal pathway in HepG2 liver cancer cells JO: Cancer Cell Int http://www.kidney.de/pget.php?&tw=1&pmid=26692820 #FOAvip BACKGROUND: Epithelial mesenchymal transition (EMT) mediated by TGF-? pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the effects of ESC on EMT in tumor cells. In this study, TGF-? was adopted to induce EMT in HepG2 cells and the influence of ESC on EMT was observed. METHODS: MTT assay was used to observe the cell viability. Wound healing assay and transwell assay were used to observe the migration and invasion activities. Western blot and immunofluorescence methods were used to observe the expression of proteins. RESULTS: We found that HepG2 cells induced by TGF-? showed mesenchymal morphology, down-regulation of epithelial marker E-cadherin and up-regulation of mesenchymal marker Vimentin, indicating that TGF-? could mediate epithelial mesenchymal induction in HepG2 cells. ESC could reverse the mesenchymal morphology and regulate expressions of marker proteins in HepG2 induced by TGF-? and significantly inhibit TGF-? induced HepG2 cell migration and invasion. We further found that ESC could also significantly depress Smad2 phosphorylation and nuclear translocation, and ESC had coordination with SB432542, a specific inhibitor of T?RI kinases. CONCLUSIONS: These results suggested that the ESC could reverse epithelial mesenchymal transition induced by TGF-? via inhibition Smad2 signaling pathway. Twit Text FOAVip ESC reverses epithelial mesenchymal transition induced by transforming growth factor- via inhibition of Smad signal pathway in HepG2 liver cancer cells ????Cancer Cell Int http://www.kidney.de/pget.php?&tw=1&pmid=26692820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26692820 #FOAvip English Wikipedia <ref>{{Cite pmid|26692820 }}</ref> ESC reverses epithelial mesenchymal transition induced by transforming growth factor-? via inhibition of Smad signal pathway in HepG2 liver cancer cells #MMPMID26692820 Liu XN ; Wang S ; Yang Q ; Wang YJ ; Chen DX ; Zhu XX Cancer Cell Int 2015[]; 15 (ä): 114 PMID26692820 show ga BACKGROUND: Epithelial mesenchymal transition (EMT) mediated by TGF-? pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the effects of ESC on EMT in tumor cells. In this study, TGF-? was adopted to induce EMT in HepG2 cells and the influence of ESC on EMT was observed. METHODS: MTT assay was used to observe the cell viability. Wound healing assay and transwell assay were used to observe the migration and invasion activities. Western blot and immunofluorescence methods were used to observe the expression of proteins. RESULTS: We found that HepG2 cells induced by TGF-? showed mesenchymal morphology, down-regulation of epithelial marker E-cadherin and up-regulation of mesenchymal marker Vimentin, indicating that TGF-? could mediate epithelial mesenchymal induction in HepG2 cells. ESC could reverse the mesenchymal morphology and regulate expressions of marker proteins in HepG2 induced by TGF-? and significantly inhibit TGF-? induced HepG2 cell migration and invasion. We further found that ESC could also significantly depress Smad2 phosphorylation and nuclear translocation, and ESC had coordination with SB432542, a specific inhibitor of T?RI kinases. CONCLUSIONS: These results suggested that the ESC could reverse epithelial mesenchymal transition induced by TGF-? via inhibition Smad2 signaling pathway. äESC reverses epithelial mesenchymal transition induced by transforming(epmc).pdf DeepDyve Pubget Overpricing