Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24777742
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Pediatr+Blood+Cancer
2014 ; 61
(9
): 1673-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Testicular tissue cryopreservation in prepubertal male children: an analysis of
parental decision-making
#MMPMID24777742
Ginsberg JP
; Li Y
; Carlson CA
; Gracia CR
; Hobbie WL
; Miller VA
; Mulhall J
; Shnorhavorian M
; Brinster RL
; Kolon TF
Pediatr Blood Cancer
2014[Sep]; 61
(9
): 1673-8
PMID24777742
show ga
BACKGROUND: Infertility is an unfortunate treatment-related consequence for some
pediatric malignancies as well as some non-malignant conditions treated with stem
cell transplant. Unlike pubertal males, prepubertal males cannot produce semen
for cryopreservation. This manuscript reports on the acceptability and safety of
a multi-institutional protocol for offering testicular tissue cryopreservation to
families of prepubertal male children at highest risk for infertility. Data on
decision influences, decision-making control, and emotional state when
considering this option are described. PROCEDURE: Prepubertal males facing
gonadotoxic therapy were offered testicular cryopreservation. Post-biopsy,
patients were followed for acute side effects. In addition, parents and patients
were asked to complete questionnaires, whether or not they chose to cryopreserve
tissue. RESULTS: Seventy-four prepubertal male children were approached.
Fifty-seven families (77%) consented to the testicular biopsy; 48 of 57 underwent
the procedure. There was one post-operative side effect. Parents who agreed to
testicular cryopreservation and those that did not felt in control of this
decision. Parents who consented to the biopsy and refusers were not deterred by
the experimental nature of the protocol. An important decision-making influence
was the risk of the biopsy. CONCLUSION: Biopsy and cryopreservation of testicular
tissue from prepubertal male children was performed successfully and safely at
three institutions. Parents faced with this option at diagnosis can make an
informed decision and weigh carefully the risks and benefits. Although asked to
make a decision soon after they were given a difficult diagnosis, parents
uniformly felt in control of this decision.