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10.1038/srep18159 http://scihub22266oqcxt.onion/10.1038/srep18159 C4676035!4676035!26655673     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26655673|t=2015. IFN-? modulates Ly-49 receptors on NK cells in IFN-?-induced pregnancy failure |pdf=|usr=}}{{26655673}} gab.com Text IFN- modulates Ly-49 receptors on NK cells in IFN- -induced pregnancy failure JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26655673 #FOAvip We have previously shown that interferon gamma (IFN-?) induces aberrant CD49b+ natural killer (NK) cell recruitment by regulating CX3CL1 and eventually provokes foetal loss. In this study, we show that IFN-? also modulates Ly-49 receptors on NK cells during pregnancy failure. The percentages of Ly-49A+ and Ly-49G2+ NK cells in the uteri of the IFN-?-treated group were significantly lower than those observed in the control group. Moreover, the median fluorescence intensity (MFI) values of Ly-49A and Ly-49G2 expression on NK cells in the uteri of the IFN-?-treated group were significantly lower than those of the control group. Using isolated spleen leucocytes, we further found that IFN-? significantly reduced the percentage of Ly-49A+ NK cells in vitro. However, CX3CL1 was not involved in the modulation of Ly-49 receptors, and the expression of CX3CR1 was not regulated by IFN-? in spleen leucocytes. Collectively, our data indicate that IFN-? can modulate Ly-49 receptors on NK cells and this process may play a role in IFN-?-induced pregnancy failure. Thus, we provide a new line of evidence correlating the deleterious effects of IFN-? with its role in regulating NK cell Ly-49 receptors during pregnancy failure. Twit Text FOAVip IFN- modulates Ly-49 receptors on NK cells in IFN- -induced pregnancy failure ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26655673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26655673 #FOAvip English Wikipedia <ref>{{Cite pmid|26655673}}</ref> IFN-? modulates Ly-49 receptors on NK cells in IFN-?-induced pregnancy failure #MMPMID26655673 Li ZY; Song ZH; Meng CY; Yang DD; Yang Y; Peng JP Sci Rep 2015[]; 5 (ä): ä PMID26655673show ga We have previously shown that interferon gamma (IFN-?) induces aberrant CD49b+ natural killer (NK) cell recruitment by regulating CX3CL1 and eventually provokes foetal loss. In this study, we show that IFN-? also modulates Ly-49 receptors on NK cells during pregnancy failure. The percentages of Ly-49A+ and Ly-49G2+ NK cells in the uteri of the IFN-?-treated group were significantly lower than those observed in the control group. Moreover, the median fluorescence intensity (MFI) values of Ly-49A and Ly-49G2 expression on NK cells in the uteri of the IFN-?-treated group were significantly lower than those of the control group. Using isolated spleen leucocytes, we further found that IFN-? significantly reduced the percentage of Ly-49A+ NK cells in vitro. However, CX3CL1 was not involved in the modulation of Ly-49 receptors, and the expression of CX3CR1 was not regulated by IFN-? in spleen leucocytes. Collectively, our data indicate that IFN-? can modulate Ly-49 receptors on NK cells and this process may play a role in IFN-?-induced pregnancy failure. Thus, we provide a new line of evidence correlating the deleterious effects of IFN-? with its role in regulating NK cell Ly-49 receptors during pregnancy failure. äIFN-? modulates Ly-49 receptors on NK cells in IFN-?-induced pregnancy(epmc).pdf DeepDyve Pubget Overpricing