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10.1016/j.apsb.2015.09.005 http://scihub22266oqcxt.onion/10.1016/j.apsb.2015.09.005 C4675814!4675814!26713275     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharm+Sin+B 2015 ; 5 (6): 590-5 Nephropedia Template TP {{tp|p=26713275|t=2015. Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis |pdf=|usr=}}{{26713275}} gab.com Text Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis JO: Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26713275 #FOAvip Curcumin, the medically active component from Curcuma longa (Turmeric), is widely used to treat inflammatory diseases. Protein interaction network (PIN) analysis was used to predict its mechanisms of molecular action. Targets of curcumin were obtained based on ChEMBL and STITCH databases. Protein?protein interactions (PPIs) were extracted from the String database. The PIN of curcumin was constructed by Cytoscape and the function modules identified by gene ontology (GO) enrichment analysis based on molecular complex detection (MCODE). A PIN of curcumin with 482 nodes and 1688 interactions was constructed, which has scale-free, small world and modular properties. Based on analysis of these function modules, the mechanism of curcumin is proposed. Two modules were found to be intimately associated with inflammation. With function modules analysis, the anti-inflammatory effects of curcumin were related to SMAD, ERG and mediation by the TLR family. TLR9 may be a potential target of curcumin to treat inflammation. Twit Text FOAVip Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis ????Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26713275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26713275 #FOAvip English Wikipedia <ref>{{Cite pmid|26713275}}</ref> Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis #MMPMID26713275 Gan Y; Zheng S; Baak JP; Zhao S; Zheng Y; Luo N; Liao W; Fu C Acta Pharm Sin B 2015[Nov]; 5 (6): 590-5 PMID26713275show ga Curcumin, the medically active component from Curcuma longa (Turmeric), is widely used to treat inflammatory diseases. Protein interaction network (PIN) analysis was used to predict its mechanisms of molecular action. Targets of curcumin were obtained based on ChEMBL and STITCH databases. Protein?protein interactions (PPIs) were extracted from the String database. The PIN of curcumin was constructed by Cytoscape and the function modules identified by gene ontology (GO) enrichment analysis based on molecular complex detection (MCODE). A PIN of curcumin with 482 nodes and 1688 interactions was constructed, which has scale-free, small world and modular properties. Based on analysis of these function modules, the mechanism of curcumin is proposed. Two modules were found to be intimately associated with inflammation. With function modules analysis, the anti-inflammatory effects of curcumin were related to SMAD, ERG and mediation by the TLR family. TLR9 may be a potential target of curcumin to treat inflammation. äPrediction of the anti-inflammatory mechanisms of curcumin by module-b(epmc).pdf DeepDyve Pubget Overpricing