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10.1186/s12882-015-0203-5 http://scihub22266oqcxt.onion/10.1186/s12882-015-0203-5 C4674950!4674950!26651477     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26651477&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Nephrol 2015 ; 16 (ä): ä Nephropedia Template TP {{tp|p=26651477|t=2015. NephroCheck data compared to serum creatinine in various clinical settings |pdf=|usr=}}{{26651477}} gab.com Text NephroCheck data compared to serum creatinine in various clinical settings JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26651477 #FOAvip Background: Acute kidney injury is frequently observed at the intensive care unit, after surgery, and after toxic drug administration. A rise in serum creatinine and a fall in urine output are consequences of much earlier injury to the most sensitive part of tubular cells located at the proximal tubule. The aim of the present study was to investigate the course of two cell-cycle arrest urinary biomarkers compared to serum creatinine in four clinical settings: ischemic reperfusion injury, cardiac failure, severe acute kidney injury, and chemotherapy-induced kidney injury. Methods: A recently developed bedside test known as NephroCheck measures two urinary parameters: insulin-like growth factor binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2). The test is based on a sandwich immunoassay technique. The final test output, labeled AKIRisk, is shown as a numeric result. Results: This report revealed that [IGFBP7]?·?[TIMP-2] in urine rise rapidly prior to any change in serum creatinine. A unique feature of all four clinical settings is that a rapid decline predicts the recovery of kidney function. Besides, a subclinical kidney injury might be detected by the test. Conclusion: This bedside test detects biomarkers of renal injury. A rapid decline in AKIRisk was associated with the restoration of kidney function, whereas a prolonged high AKIRisk score was associated with end-stage renal disease. However, the dynamics seem to differ, depending on the cause and the extent of injury. Further studies will be needed to clarify the issue. Electronic supplementary material: The online version of this article (doi:10.1186/s12882-015-0203-5) contains supplementary material, which is available to authorized users. Twit Text FOAVip NephroCheck data compared to serum creatinine in various clinical settings ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26651477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26651477 #FOAvip English Wikipedia <ref>{{Cite pmid|26651477}}</ref> NephroCheck data compared to serum creatinine in various clinical settings #MMPMID26651477 Pajenda S; Ilhan-Mutlu A; Preusser M; Roka S; Druml W; Wagner L BMC Nephrol 2015[]; 16 (ä): ä PMID26651477show ga Background: Acute kidney injury is frequently observed at the intensive care unit, after surgery, and after toxic drug administration. A rise in serum creatinine and a fall in urine output are consequences of much earlier injury to the most sensitive part of tubular cells located at the proximal tubule. The aim of the present study was to investigate the course of two cell-cycle arrest urinary biomarkers compared to serum creatinine in four clinical settings: ischemic reperfusion injury, cardiac failure, severe acute kidney injury, and chemotherapy-induced kidney injury. Methods: A recently developed bedside test known as NephroCheck measures two urinary parameters: insulin-like growth factor binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2). The test is based on a sandwich immunoassay technique. The final test output, labeled AKIRisk, is shown as a numeric result. Results: This report revealed that [IGFBP7]?·?[TIMP-2] in urine rise rapidly prior to any change in serum creatinine. A unique feature of all four clinical settings is that a rapid decline predicts the recovery of kidney function. Besides, a subclinical kidney injury might be detected by the test. Conclusion: This bedside test detects biomarkers of renal injury. A rapid decline in AKIRisk was associated with the restoration of kidney function, whereas a prolonged high AKIRisk score was associated with end-stage renal disease. However, the dynamics seem to differ, depending on the cause and the extent of injury. Further studies will be needed to clarify the issue. Electronic supplementary material: The online version of this article (doi:10.1186/s12882-015-0203-5) contains supplementary material, which is available to authorized users. äNephroCheck data compared to serum creatinine in various clinical sett(epmc).pdf DeepDyve Pubget Overpricing