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10.1186/s40478-015-0258-3 http://scihub22266oqcxt.onion/10.1186/s40478-015-0258-3 C4674944!4674944!26651821     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol+Commun 2015 ; 3 (ä): ä Nephropedia Template TP {{tp|p=26651821|t=2015. The domestic cat as a natural animal model of Alzheimer?s disease |pdf=|usr=}}{{26651821}} gab.com Text The domestic cat as a natural animal model of Alzheimer s disease JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=26651821 #FOAvip Introduction: Alzheimer?s disease (AD) is the most dominant neurodegenerative disorder that causes dementia, and no effective treatments are available. To study its pathogenesis and develop therapeutics, animal models representing its pathologies are needed. Although many animal species develop senile plaques (SP) composed of amyloid-? (A?) proteins that are identical to those found in humans, none of them exhibit neurofibrillary tangles (NFT) and subsequent neurodegeneration, which are integral parts of the pathology of AD. Results: The present study shows that A? accumulation, NFT formation, and significant neuronal loss all emerge naturally in the hippocampi of aged domestic cats. The NFT that form in the cat brain are identical to those seen in human AD in terms of their spatial distribution, the cells they affect, and the tau isoforms that comprise them. Interestingly, aged cats do not develop mature argyrophilic SP, but instead accumulate intraneuronal A? oligomers in their hippocampal pyramidal cells, which might be due to the amino acid sequence of felid A?. Conclusions: These results suggest that A? oligomers are more important than SP for NFT formation and the subsequent neurodegeneration. The domestic cat is a unique animal species that naturally replicates various AD pathologies, especially A? oligomer accumulation, NFT formation, and neuronal loss. Electronic supplementary material: The online version of this article (doi:10.1186/s40478-015-0258-3) contains supplementary material, which is available to authorized users. Twit Text FOAVip The domestic cat as a natural animal model of Alzheimer s disease ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=26651821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26651821 #FOAvip English Wikipedia <ref>{{Cite pmid|26651821}}</ref> The domestic cat as a natural animal model of Alzheimer?s disease #MMPMID26651821 Chambers JK; Tokuda T; Uchida K; Ishii R; Tatebe H; Takahashi E; Tomiyama T; Une Y; Nakayama H Acta Neuropathol Commun 2015[]; 3 (ä): ä PMID26651821show ga Introduction: Alzheimer?s disease (AD) is the most dominant neurodegenerative disorder that causes dementia, and no effective treatments are available. To study its pathogenesis and develop therapeutics, animal models representing its pathologies are needed. Although many animal species develop senile plaques (SP) composed of amyloid-? (A?) proteins that are identical to those found in humans, none of them exhibit neurofibrillary tangles (NFT) and subsequent neurodegeneration, which are integral parts of the pathology of AD. Results: The present study shows that A? accumulation, NFT formation, and significant neuronal loss all emerge naturally in the hippocampi of aged domestic cats. The NFT that form in the cat brain are identical to those seen in human AD in terms of their spatial distribution, the cells they affect, and the tau isoforms that comprise them. Interestingly, aged cats do not develop mature argyrophilic SP, but instead accumulate intraneuronal A? oligomers in their hippocampal pyramidal cells, which might be due to the amino acid sequence of felid A?. Conclusions: These results suggest that A? oligomers are more important than SP for NFT formation and the subsequent neurodegeneration. The domestic cat is a unique animal species that naturally replicates various AD pathologies, especially A? oligomer accumulation, NFT formation, and neuronal loss. Electronic supplementary material: The online version of this article (doi:10.1186/s40478-015-0258-3) contains supplementary material, which is available to authorized users. äThe domestic cat as a natural animal model of Alzheimer?s disease (epmc).pdf DeepDyve Pubget Overpricing