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10.1186/1471-2105-16-S17-S5 http://scihub22266oqcxt.onion/10.1186/1471-2105-16-S17-S5 C4674855!4674855!26679199     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Bioinformatics 2015 ; 16 (Suppl 17): S5 Nephropedia Template TP {{tp|p=26679199|t=2015. A computational method for drug repositioning using publicly available gene expression data |pdf=|usr=}}{{26679199}} gab.com Text A computational method for drug repositioning using publicly available gene expression data JO: BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=26679199 #FOAvip Motivation: The identification of new therapeutic uses of existing drugs, or drug repositioning, offers the possibility of faster drug development, reduced risk, lesser cost and shorter paths to approval. The advent of high throughput microarray technology has enabled comprehensive monitoring of transcriptional response associated with various disease states and drug treatments. This data can be used to characterize disease and drug effects and thereby give a measure of the association between a given drug and a disease. Several computational methods have been proposed in the literature that make use of publicly available transcriptional data to reposition drugs against diseases. Method: In this work, we carry out a data mining process using publicly available gene expression data sets associated with a few diseases and drugs, to identify the existing drugs that can be used to treat genes causing lung cancer and breast cancer. Results: Three strong candidates for repurposing have been identified- Letrozole and GDC-0941 against lung cancer, and Ribavirin against breast cancer. Letrozole and GDC-0941 are drugs currently used in breast cancer treatment and Ribavirin is used in the treatment of Hepatitis C. Twit Text FOAVip A computational method for drug repositioning using publicly available gene expression data ????BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=26679199 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26679199 #FOAvip English Wikipedia <ref>{{Cite pmid|26679199}}</ref> A computational method for drug repositioning using publicly available gene expression data #MMPMID26679199 Shabana K; Abdul Nazeer K; Pradhan M; Palakal M BMC Bioinformatics 2015[]; 16 (Suppl 17): S5 PMID26679199show ga Motivation: The identification of new therapeutic uses of existing drugs, or drug repositioning, offers the possibility of faster drug development, reduced risk, lesser cost and shorter paths to approval. The advent of high throughput microarray technology has enabled comprehensive monitoring of transcriptional response associated with various disease states and drug treatments. This data can be used to characterize disease and drug effects and thereby give a measure of the association between a given drug and a disease. Several computational methods have been proposed in the literature that make use of publicly available transcriptional data to reposition drugs against diseases. Method: In this work, we carry out a data mining process using publicly available gene expression data sets associated with a few diseases and drugs, to identify the existing drugs that can be used to treat genes causing lung cancer and breast cancer. Results: Three strong candidates for repurposing have been identified- Letrozole and GDC-0941 against lung cancer, and Ribavirin against breast cancer. Letrozole and GDC-0941 are drugs currently used in breast cancer treatment and Ribavirin is used in the treatment of Hepatitis C. äA computational method for drug repositioning using publicly available(epmc).pdf DeepDyve Pubget Overpricing