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10.1016/j.amjmed.2013.02.016 http://scihub22266oqcxt.onion/10.1016/j.amjmed.2013.02.016 C4674813!4674813!23885678     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Med 2013 ; 126 (8): 730.e9-730.e17 Nephropedia Template TP {{tp|p=23885678|t=2013. The Relationship of Cardiovascular Risk in Rheumatoid Arthritis Comparing TNF? Blockade with Non-Biologic DMARDs |pdf=|usr=}}{{23885678}} gab.com Text The Relationship of Cardiovascular Risk in Rheumatoid Arthritis Comparing TNF Blockade with Non-Biologic DMARDs JO: Am J Med http://www.kidney.de/pget.php?&tw=1&pmid=23885678 #FOAvip Background: Elevated TNF? likely contributes to the excess cardiovascular risk observed in rheumatoid arthritis. We compared the cardiovascular risk in rheumatoid arthritis patients starting a TNF? blocking agent versus a non-biologic disease-modifying anti-rheumatic drug (nbDMARD). Methods: Subjects with rheumatoid arthritis participating in several different US insurance programs between 1998-2007 who received methotrexate were eligible. Those who added a TNF? blocking agent were compared with subjects who added a nbDMARD in Cox regression models stratified by propensity score decile and adjusted for oral glucocorticoid dosage. We examined the composite cardiovascular endpoint of myocardial infarction, stroke, or coronary re-vascularization after six months. Results: We compared 8,656 new users of a nbDMARD with 11,587 new users of a TNF? blocking agent with similar baseline covariates. Incidence rates per 100 person-years for the composite cardiovascular endpoint were 3.05 (95% CI 2.54 ? 3.65) for nbDMARDs and 2.52 (95% CI 2.12-2.98) for TNF? blocking agents. The hazard ratio (HR) for the TNF? blocking agent compared with nbDMARD carrying the first exposure forward was 0.80 (95% CI 0.62 - 1.04), while the HR for the as-treated analysis was 0.71 (95% CI 0.52 - 0.97). The potential cardiovascular benefit of TNF? blocking agents was strongest among persons ? 65 years of age (HR 0.52, 95% CI 0.34 ? 0.77; p for interaction = 0.075). Conclusion: Among subjects with rheumatoid arthritis, TNF? blocking agents may be associated with a reduced risk of cardiovascular events compared to a nbDMARD. Randomized controlled clinical trials should be considered to test this hypothesis. Twit Text FOAVip The Relationship of Cardiovascular Risk in Rheumatoid Arthritis Comparing TNF Blockade with Non-Biologic DMARDs ????Am J Med http://www.kidney.de/pget.php?&tw=1&pmid=23885678 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23885678 #FOAvip English Wikipedia <ref>{{Cite pmid|23885678}}</ref> The Relationship of Cardiovascular Risk in Rheumatoid Arthritis Comparing TNF? Blockade with Non-Biologic DMARDs #MMPMID23885678 Solomon DH; Curtis JR; Saag KG; Lii J; Chen L; Harrold LR; Herrinton LJ; Graham DJ; Kowal MK; Kuriya B; Liu L; Griffin MR; Lewis JD; Rassen JA Am J Med 2013[Aug]; 126 (8): 730.e9-730.e17 PMID23885678show ga Background: Elevated TNF? likely contributes to the excess cardiovascular risk observed in rheumatoid arthritis. We compared the cardiovascular risk in rheumatoid arthritis patients starting a TNF? blocking agent versus a non-biologic disease-modifying anti-rheumatic drug (nbDMARD). Methods: Subjects with rheumatoid arthritis participating in several different US insurance programs between 1998-2007 who received methotrexate were eligible. Those who added a TNF? blocking agent were compared with subjects who added a nbDMARD in Cox regression models stratified by propensity score decile and adjusted for oral glucocorticoid dosage. We examined the composite cardiovascular endpoint of myocardial infarction, stroke, or coronary re-vascularization after six months. Results: We compared 8,656 new users of a nbDMARD with 11,587 new users of a TNF? blocking agent with similar baseline covariates. Incidence rates per 100 person-years for the composite cardiovascular endpoint were 3.05 (95% CI 2.54 ? 3.65) for nbDMARDs and 2.52 (95% CI 2.12-2.98) for TNF? blocking agents. The hazard ratio (HR) for the TNF? blocking agent compared with nbDMARD carrying the first exposure forward was 0.80 (95% CI 0.62 - 1.04), while the HR for the as-treated analysis was 0.71 (95% CI 0.52 - 0.97). The potential cardiovascular benefit of TNF? blocking agents was strongest among persons ? 65 years of age (HR 0.52, 95% CI 0.34 ? 0.77; p for interaction = 0.075). Conclusion: Among subjects with rheumatoid arthritis, TNF? blocking agents may be associated with a reduced risk of cardiovascular events compared to a nbDMARD. Randomized controlled clinical trials should be considered to test this hypothesis. äThe Relationship of Cardiovascular Risk in Rheumatoid Arthritis Compar(epmc).pdf DeepDyve Pubget Overpricing