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10.1038/ncomms10047 http://scihub22266oqcxt.onion/10.1038/ncomms10047 C4674682!4674682!26616214     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26616214|t=2015. The epigenomic landscape of African rainforest hunter-gatherers and farmers |pdf=|usr=}}{{26616214}} gab.com Text The epigenomic landscape of African rainforest hunter-gatherers and farmers JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26616214 #FOAvip The genetic history of African populations is increasingly well documented, yet their patterns of epigenomic variation remain uncharacterized. Moreover, the relative impacts of DNA sequence variation and temporal changes in lifestyle and habitat on the human epigenome remain unknown. Here we generate genome-wide genotype and DNA methylation profiles for 362 rainforest hunter-gatherers and sedentary farmers. We find that the current habitat and historical lifestyle of a population have similarly critical impacts on the methylome, but the biological functions affected strongly differ. Specifically, methylation variation associated with recent changes in habitat mostly concerns immune and cellular functions, whereas that associated with historical lifestyle affects developmental processes. Furthermore, methylation variation?particularly that correlated with historical lifestyle?shows strong associations with nearby genetic variants that, moreover, are enriched in signals of natural selection. Our work provides new insight into the genetic and environmental factors affecting the epigenomic landscape of human populations over time. Twit Text FOAVip The epigenomic landscape of African rainforest hunter-gatherers and farmers ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26616214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26616214 #FOAvip English Wikipedia <ref>{{Cite pmid|26616214}}</ref> The epigenomic landscape of African rainforest hunter-gatherers and farmers #MMPMID26616214 Fagny M; Patin E; MacIsaac JL; Rotival M; Flutre T; Jones MJ; Siddle KJ; Quach H; Harmant C; McEwen LM; Froment A; Heyer E; Gessain A; Betsem E; Mouguiama-Daouda P; Hombert JM; Perry GH; Barreiro LB; Kobor MS; Quintana-Murci L Nat Commun 2015[]; 6 (ä): ä PMID26616214show ga The genetic history of African populations is increasingly well documented, yet their patterns of epigenomic variation remain uncharacterized. Moreover, the relative impacts of DNA sequence variation and temporal changes in lifestyle and habitat on the human epigenome remain unknown. Here we generate genome-wide genotype and DNA methylation profiles for 362 rainforest hunter-gatherers and sedentary farmers. We find that the current habitat and historical lifestyle of a population have similarly critical impacts on the methylome, but the biological functions affected strongly differ. Specifically, methylation variation associated with recent changes in habitat mostly concerns immune and cellular functions, whereas that associated with historical lifestyle affects developmental processes. Furthermore, methylation variation?particularly that correlated with historical lifestyle?shows strong associations with nearby genetic variants that, moreover, are enriched in signals of natural selection. Our work provides new insight into the genetic and environmental factors affecting the epigenomic landscape of human populations over time. äThe epigenomic landscape of African rainforest hunter-gatherers and fa(epmc).pdf DeepDyve Pubget Overpricing